other brands: NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscienceproduct type: antibodyproduct name: CD105 Monoclonal Antibody (SN6h)catalog: MA5-11854quantity: 500µLprice: US 338clonality: monoclonalhost: mouseconjugate: nonconjugatedclone name: reactivity: human, cow, pig, rabbitapplication: western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, blocking or activating experimentsmore info or order: Invitrogen product webpagePublished Application/Species/Sample/DilutionReferenceflow cytometry; human; fig1Yin T, He S, Su C, Chen X, Zhang D, Wan Y, et al. Genetically modified human placenta‑derived mesenchymal stem cells with FGF‑2 and PDGF‑BB enhance neovascularization in a model of hindlimb ischemia. Mol Med Rep. 2015;12:5093-9 pubmedpublisher immunohistochemistry; human; 1:50Gurzu S, Ciortea D, Tamasi A, Golea M, Bodi A, Sahlean D, et al. The immunohistochemical profile of granular cell (Abrikossoff) tumor suggests an endomesenchymal origin. Arch Dermatol Res. 2015;307:151-7 pubmedpublisher immunohistochemistry - paraffin section; human; 1:100Lytras D, Leontara V, Kefala M, Foukas P, Giannakou N, Pouliakis A, et al. Microvessel Landscape Assessment in Pancreatic Ductal Adenocarcinoma: Unclear Value of Targeting Endoglin (CD105) as Prognostic Factor of Clinical Outcome. Pancreas. 2015;44:87-92 pubmedpublisher immunocytochemistry; humanYuan S, Guo Y, Zhou X, Shen W, Chen H. PDGFR-? (+) perivascular cells from infantile hemangioma display the features of mesenchymal stem cells and show stronger adipogenic potential in vitro and in vivo. Int J Clin Exp Pathol. 2014;7:2861-70 pubmed immunohistochemistry - paraffin section; rabbit; 1:75Wen Q, Zhou C, Luo W, Zhou M, Ma L. Pro-osteogenic effects of fibrin glue in treatment of avascular necrosis of the femoral head in vivo by hepatocyte growth factor-transgenic mesenchymal stem cells. J Transl Med. 2014;12:114 pubmedpublisher immunohistochemistry; human; 1:50Clara C, Marie S, de Almeida J, Wakamatsu A, Oba Shinjo S, Uno M, et al. Angiogenesis and expression of PDGF-C, VEGF, CD105 and HIF-1? in human glioblastoma. Neuropathology. 2014;34:343-52 pubmedpublisher immunohistochemistry; humanAkdur N, Donmez M, Gözel S, Ustun H, Hucumenoglu S. Intravascular papillary endothelial hyperplasia: histomorphological and immunohistochemical features. Diagn Pathol. 2013;8:167 pubmedpublisher immunohistochemistry; human; 1:50Gurzu S, Ciortea D, Munteanu T, Kezdi Zaharia I, Jung I. Mesenchymal-to-endothelial transition in Kaposi sarcoma: a histogenetic hypothesis based on a case series and literature review. PLoS ONE. 2013;8:e71530 pubmedpublisher blocking or activating experiments; humanNolan Stevaux O, Zhong W, Culp S, Shaffer K, Hoover J, Wickramasinghe D, et al. Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies. PLoS ONE. 2012;7:e50920 pubmedpublisher immunohistochemistry - paraffin section; rabbit; fig3Wen Q, Jin D, Zhou C, Zhou M, Luo W, Ma L. HGF-transgenic MSCs can improve the effects of tissue self-repair in a rabbit model of traumatic osteonecrosis of the femoral head. PLoS ONE. 2012;7:e37503 pubmedpublisher immunocytochemistry; humanYuan S, Chen R, Shen W, Chen H, Zhou X. Mesenchymal stem cells in infantile hemangioma reside in the perivascular region. Pediatr Dev Pathol. 2012;15:5-12 pubmedpublisher immunohistochemistry; human; 1:40Alkhabuli J. Significance of neo-angiogenesis and immuno-surveillance cells in squamous cell carcinoma of the tongue. Libyan J Med. 2007;2:30-9 pubmedpublisher flow cytometry; pigZhang X, Xu Y, Thomas V, Bellis S, Vohra Y. Engineering an antiplatelet adhesion layer on an electrospun scaffold using porcine endothelial progenitor cells. J Biomed Mater Res A. 2011;97:145-51 pubmedpublisher flow cytometry; human; 1:50Zhao J, Gao Z, Mei H, Li Y, Wang Y. Differentiation of human mesenchymal stem cells: the potential mechanism for estrogen-induced preferential osteoblast versus adipocyte differentiation. Am J Med Sci. 2011;341:460-8 pubmedpublisher immunohistochemistry; human; 1:50Jung I, Gurzu S, Raica M, Cimpean A, Szentirmay Z. The differences between the endothelial area marked with CD31 and CD105 in colorectal carcinomas by computer-assisted morphometrical analysis. Rom J Morphol Embryol. 2009;50:239-43 pubmed immunohistochemistry; humanGurzu S, Jung I, Prantner I, Ember I, Pávai Z, Mezei T. The expression of cytoskeleton regulatory protein Mena in colorectal lesions. Rom J Morphol Embryol. 2008;49:345-9 pubmed immunohistochemistry; humanGurzu S, Jung J, Azamfirei L, Mezei T, Cimpean A, Szentirmay Z. The angiogenesis in colorectal carcinomas with and without lymph node metastases. Rom J Morphol Embryol. 2008;49:149-52 pubmed immunohistochemistry; humanGurzu S, Jung J, Azamfirei L, Mezei T, Cimpean A. The aspects of angiogenesis in anal canal carcinomas compared with that in colorectal carcinomas. Rom J Morphol Embryol. 2007;48:349-53 pubmed western blot; humanEinspahr J, Thomas T, Saboda K, Nickolof B, Warneke J, Curiel Lewandrowski C, et al. Expression of vascular endothelial growth factor in early cutaneous melanocytic lesion progression. Cancer. 2007;110:2519-27 pubmed immunocytochemistry; humanSchlabe J, Johnen C, Schwartlander R, Moser V, Hartmann B, Gerlach J, et al. Isolation and culture of different epidermal and dermal cell types from human scalp suitable for the development of a therapeutical cell spray. Burns. 2008;34:376-84 pubmed immunocytochemistry; humanDuret C, Gerbal Chaloin S, Ramos J, Fabre J, Jacquet E, Navarro F, et al. Isolation, characterization, and differentiation to hepatocyte-like cells of nonparenchymal epithelial cells from adult human liver. Stem Cells. 2007;25:1779-90 pubmed immunohistochemistry; human; 0.4 mg/lYu J, Cui L, Zhang Q, Chen H, Ji P, Wei H, et al. Expression of NOS and HIF-1alpha in human colorectal carcinoma and implication in tumor angiogenesis. World J Gastroenterol. 2006;12:4660-4 pubmed immunohistochemistry; human; 1:100Yang L, Lu W, Huang G, Wang W. Correlation between CD105 expression and postoperative recurrence and metastasis of hepatocellular carcinoma. BMC Cancer. 2006;6:110 pubmed flow cytometry; humanHe X, Li Y, Wang X, Guo X, Niu Y. [Mesenchymal stem cells transduced by PLEGFP-N1 retroviral vector maintain their biological features and differentiation]. Chin Med J (Engl). 2005;118:1728-34 pubmedWurmser A, Nakashima K, Summers R, Toni N, D Amour K, Lie D, et al. Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Nature. 2004;430:350-6 pubmed image 1: Formalin-fixed, paraffin-embedded human tonsil stained with CD105 antibody using peroxidase-conjugate and AEC chromogen. Note staining of endothelial cells.Applications: Flow Cytometry: 0.5-1 µg/test, Immunofluorescence: 1:10-1:100, Immunohistochemistry (Paraffin): 1:100 - 200, Western Blot: 1-2 µg/mLSpecies: Bovine, HumanClone: Isotype: IgG1, kappaStorage: Description: CD105 or Endoglin or GP160 is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists as an O- and N-glycosylated homodimer. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial cell marker. CD105 binds to TGF-Beta1 and Beta3 with high affinity but not TGF-Beta2.Immunogen: Purified GP160 from cell membrane glycoproteins of fresh non-T/non-B acute lymphoblastic leukemia cellsFormat: LiquidApplications w/Dilutions: Flow Cytometry: 0.5-1 µg/test, Immunofluorescence: 1:10-1:100, Immunohistochemistry (Paraffin): 1:100 - 200, Western Blot: 1-2 µg/mLAliases: CD105, END, HHT1, ORW, ORW1, CD105 antigen, ENGmore info or order: Invitrogen product webpageThermo Fisher Scientific81 Wyman StreetWaltham, MA USA 02451https://www.thermofisher.com800-678-5599headquarters: USA