Fitzgerald/Paraoxonase 1 antibody/10R-8414/100 ul
OVERVIEW:
Synonyms | Monoclonal Paraoxonase 1 antibody, Anti-Paraoxonase 1 antibody, PON1 antibody, paraoxonase 1 antibody, A-esterase 1 antibody, aromatic esterase 1 antibody, arylesterase B-type antibody, BOS_4019 antibody, EGK_13925 antibody, ESA antibody, esterase A antibody, K-45 antibody, MVCD5 antibody, paraoxonase B-type antibody, Pon antibody, PON 1 antibody, serum aryldiakylphosphatase antibody, serum aryldialkylphosphatase 1 antibody, serum paraoxonase antibody, serum paraoxonase/arylesterase 1 antibody |
Cross Reactivity | Human, Mouse, Rat |
Applications | WB |
Immunogen | Paraoxonase 1 antibody was raised in Mouse using a His-tagged recombinant human PON1 protein purified E.coli as the immunogen |
SPECIFICATIONS:
Host | Mouse |
Clone | 17A12 |
Isotype | IgG1 kappa |
Method of Purification | Paraoxonase 1 antibody was purified by ammonium sulfate precipitation |
Form & Buffer | Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol |
STORAGE & SAFETY:
Storage | Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles |
Usage Assay Information:
Usage Recommendations | WB: 1:500 |
GENERAL INFORMATION:
Biological Significance | The paraoxonase (PON) gene-family in humans has three members, PON1, PON2, and PON3, aligned next to each other on the long arm of chromosome 7q21.3-22.1. PON1 of these is synthesized primarily in the liver and a portion is secreted into the plasma, where it is associated with high density lipoproteins (HDL). And It hydrolyzes the active metabolites of several other organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon), as well as nerve agents such as sarin, soman and VX (lethal nerve agent). The PON1 polymorphism may be responsible for neurodegeneration and considered to be an independent risk factor for Parkinson?s disease. |
