Adipogen/PMPH/AG-CR1-3905-M005/5 mg-蚂蚁淘生物

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4-((1H-Pyrazol-1-yl)methyl)-N-hydroxybenzamide

Chemical

C₁₁H₁₁N₃O₂

217.2

1392835-64-1

≥98% (HPLC)

Off-white solid.

Soluble in DMSO, methanol or ethanol.

Determined by ¹H-NMR.

DUGDSZFLAKVUEC-UHFFFAOYSA-N

AMBIENT

+4°C

-20°C

Keep cool and dry.Protect from light.

Stable for at least 2 years after receipt when stored at -20°C.

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Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC₅₀ =11nM). Displays high selectivity over HDAC1 (IC₅₀=1.5µM).
Neuroprotective. Effectively prevents neuronal cell death upon oxidative stress induction by HCA and selectively induces cellular α-tubulin hyperacetylation.
HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.

Product References

Bicyclic-capped histone deacetylase 6 inhibitors with improved activity in a model of axonal charcot-marie-tooth disease: S. Shen, et al.; ACS Chemical Neuroscience (submitted) (2015)

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