产品说明
Catalog#:1807ScientificName:L-threo-Dihydrosphingosine(Safingol)CommonName:L-threo-Sphinganine,C18chainActivity:ProteinKinaseC(PKC)andSphingosineKinaseinhibitorEmpiricalFormula:C18H39NO2CAS#15639-50-6SDSViewSafetyDataSheetDataSheet:ViewDataSheetFormulaWeight:301Unit:5mgSolvent:noneSource:syntheticPurity:98+%AnalyticalMethods:TLC,GCMeltingPoint:103-114°CSolubility:chloroform,methanol,ethanol,DMSOPhysicalAppearance:solidStorage:-20°CDryIce:NoHazardous:NoLiteratureReferences:1.Darges,etal.“InhibitionofleukotrieneB4(LTB4)inhumanneutrophilsbyL-threo-dihydrosphingosine”Adv.Exp.Med.Biol,Vol.400App.387-392,19972.G.Schwartz,etal.“Apilotclinical/pharmacologicalstudyoftheproteinkinaseC-specificinhibitorsafingolaloneandincombinationwithdoxorubicin”Clin.CancerRes,Vol.3pp.537-543,19973.J.Cowardetal.“Safingol(L-threo-sphinganine)inducesautophagyinsolidtumorcellsthroughinhibitionofPKCandthePI3-kinasepathway”AutophagyVol.5(2)pp.184-193,20094.M.Dragusinetal.“Metabolismoftheunnaturalanticancerlipidsafingol,L-threo-dihydrosphingosine,inculturedcells”Vol.44pp.1772,2003
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