产品说明
Catalog#:1889ScientificName:ConduritolBEpoxideCommonName:D,L-1,2-Anhydro-myo-inositol;Activity:Inhibitsalpha-glucosidaseactivity;specificinhibitorofglucocerebrosidaseinculturedcellsEmpiricalFormula:C6H10O5CAS#6090-95-5SDSViewSafetyDataSheetDataSheet:ViewDataSheetFormulaWeight:162Unit:25mgSolvent:noneSource:syntheticPurity:98+%AnalyticalMethods:TLC,identityconfirmedbyMSNaturalSource:n/aMeltingPoint:164-166°CSolubility:water,DMSO,methanol(slightly)PhysicalAppearance:solidStorage:-20°CDryIce:NoHazardous:NoLiteratureReferences:1.G.Grabowskietal.“Gaucherdiseasetypes1,2,and3:differentialmutationsoftheacidbeta-glucosidaseactivesiteidentifiedwithconduritolBepoxidederivativesandsphingosine”AmJHumGenet.,Vol.37pp.499-510,19852.S.Yangetal.“Inactivationofalpha-glucosidasebytheactive-site-directedinhibitor,conduritolBepoxide”BiochimBiophysActa,Vol.828(3)pp.236-240,19853.L.Premkumaretal.“X-rayStructureofHumanAcid-beta-GlucosidaseCovalentlyBoundtoConduritol-B-EpoxideImplicationsforGaucherDisease”TheJournalofBIOLOGicalChemistry,Vol.280(25)pp.23815-23819,20054.G.Grabowskietal.“Humanacidbeta-glucosidase.UseofconduritolBepoxidederivativestoinvestigatethecatalyticallyactivenormalandGaucherdiseaseenzymes”TheJournalofBiologicalChemistry,Vol.261(18)pp.8263-8269,19865.E.Korkotianetal.“ElevationofIntracellularGlucosylceramideLevelsResultsinanIncreaseinEndoplasmicReticulumDensityandinFunctionalCalciumStoresinCulturedNeurons”TheJournalofBiologicalChemistry,Vol.274(31)pp.21673-21678,1999
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