•

Agonists

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ScreeningLibraries

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OSMI-1

Cat.No.:

HY-119738

CASNo.:

1681056-61-0

分⼦式:

C

₂₈H₂₅N₃O₆S₂

分⼦量:

563.64

作⽤靶点:

Others

作⽤通路:

Others

储存⽅式:

Pleasestoretheproductundertherecommendedconditionsin

theCOA.

BIOLOGICALACTIVITY

⽣物活性

OSMI-1是⼀种可渗透细胞的O-GlcNAc转移酶(OGT)抑制剂，IC50值为2.7μM。OSMI-1抑制哺乳动物细胞

系中的蛋⽩O-连接的N-⼄酰氨基葡萄糖(O-GlcNAcylation)，⽽没有定性地改变细胞表⾯N-或O-连接的聚糖

。

IC

50

Target

IC50:2.7μM(O-GlcNActransferase)[1]

OSMI-1(50μM;24hours;CHOcells)treatmentdecreasestheviabilitybyabout50%after24hours[1].

OSMI-1(10-100μM;24hours;CHOcells)treatmentreducesglobalO-linkedN-acetylglucosamine(O-

GlcNAcylation)adose-dependentmanner.OSMI-1inhibitsOGTactivityincells[1].

CellViabilityAssay[1]

CellLine:

CHOcells

Concentration:

50μM

IncubationTime:

24hours

Result:

Viabilitydecreasedbyabout50%after24hours.

WesternBlotAnalysis[1]

CellLine:

CHOcells

Concentration:

10μM,25μM,50μM,100μM

体外研究

1/2

MasterofSmallMolecules

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