Adipogen/OM173-αA/AG-CN2-0158-M005/5 mg
More Information Product Details
Synonyms | Nanaomycin αA |
Product Type | Chemical |
Properties
Formula | C17H16O6 |
MW | 316.3 |
CAS | 58286-56-9 |
Source/Host Chemicals | Isolated from Streptomyces sp. |
Purity Chemicals | ≥95% (HPLC) |
Appearance | Yellow solid. |
Solubility | Soluble in DMSO, ethanol or methanol. |
Declaration | Manufactured by BioLinks K.K. with courtesy strain from The Kitasato Institute. |
InChi Key | FMEUWIKCSICJBO-DTWKUNHWSA-N |
Shipping and Handling
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Keep cool and dry. |
Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Documents
MSDS ![](\"https://www.ebiomall.com/images/adipogen/download.png\") Download PDF |
Product Specification Sheet
Datasheet | Download PDF |
- Antibiotic [1-3].
- Antimycoplasma [1, 3, 4].
- Antifungal compound [1, 3].
- Anti-malarial agent [5].
- Ras-competitive non-CAAX mimetic type farnesyltransferase (FTase) inhibitor [6].
- Potential anticancer compound. Inducer of antiproliferative effects in tumor cell lines [6-8].
- Selective DNA (cytosine-5)-methyltransferase 3B (DNMT3B) inhibitor [8].
Product References
Nanaomycins, new antibiotics produced by a strain of Streptomyces. I. Taxonomy, isolation, characterization and biological properties: H. Tanaka, et al.; J. Antibiot. 28, 860 (1975)Nanomycins, new antibiotics produced by a strain of Streptomyces. II. Structure and biosynthesis: H. Tanaka, et al.; J. Antibiot. 28, 868 (1975)Nanaomycins, new antibiotics produced by a strain of Streptomyces. III. A new component, nanaomycin C, and biological activities of nanaomycin derivatives: H. Tanaka, et al.; J. Antibiot. 28, 925 (1975)OM-173, new nanaomycin-type antibiotics produced by a strain of Streptomyces. Taxonomy, production, isolation and biological properties: Y. Iway, et al.; J. Antibiot. 36, 1268 (1983)Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol: Y. Tanaka, et al.; J. Antibiot. 52, 880 (1999)UCF76 compounds, new inhibitors of farnesyltransferase produced by Streptomyces: M. Hara, et al.; J. Antibiot. 54, 182 (2001)Total synthesis and development of bioactive natural products: T. Kuniaki; Proc. Jpn. Acad. Ser. B. Phys. Biol. Sci. 84, 87 (2008)Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells: D. Kuck, et al.; Mol. Cancer Ther. 9, 3015 (2010)
