Rabbit polyclonal antibody

Antigen/Purification: ExpandCollapse

The antigen is a peptide corresponding to amino acid residues from the C-terminal region of rat APP.

The antibody is prepared from pooled rabbit serum by affinity purification on a column made with the C-terminal peptide used as antigen.

Biological Significance: ExpandCollapse

A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer’s disease (AD) (Kamenetz et al., 2003). The phosphorylation of APP at Thr⁶⁶⁸ is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid peptide (abeta) which are the major components of senile plaques in patient brains inflicted with AD (Liu et al., 2003; Ando et al., 2001).

Storage

100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

For long term storage –20° C is recommended. Stable at –20° C for at least 1 year.

General References