The 5A1 monoclonal antibody reacts with mouse colony stimulating factor 1 (CSF1) also known as macrophage colony-stimulating factor (M-CSF). CSF1 is a hematopoietic growth factor that is expressed by many different cell types including fibroblasts, stromal cells, osteoblasts, activated T cells, macrophages, and B cells. CSF1 plays a role in regulating the proliferation, differentiation and survival of monocytes, macrophages, and bone marrow progenitor cells. CSF1 produced in vessel walls is thought to contribute to the development and progression of atherosclerosis. The 5A1 antibody has been shown to neutralize CSF1 in vivo.
| Isotype | Rat IgG1, κ |
| Recomended Isotype Control(s) | InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidaseInVivoMAb rat IgG1 Isotype control, anti-trinitrophenol |
| Recommended InVivoPure Dilution Buffer | InVivoPure pH 8.0 Dilution Buffer |
| Immunogen | Purified mouse CSF-1 |
| Reported Applications | in vivo CSF1 neutralization |
| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2 μM filtered |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein G |
| Storage | Undiluted at 4°C in the dark |
