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Selleckchem/Pyrrolidinedithiocarbamate ammonium/S3633

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S3633

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Selleck Chemicals

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DescriptionAmmonium pyrrolidine dithiocarbamate (PDTC) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.TargetsNF-κB [1]()In vitroAmmonium pyrrolidine dithiocarbamate (PDTC) can inhibit the role of NF-κB by inhibiting IκB phosphorylation, thus blocking NF-κB translocation to the nucleus, reducing the expression of downstream cytokines[1]. AssayMethodsTest IndexPMIDWestern blotp-p65 / p65 / p50 ;PubMed: 29956738Int J OncolFollowing treatment with EMCL at the indicated doses and PDTC (30µM) for 24 h, cytoplasmic and nuclear extracts were prepared for the western blot analysis of p-p65, p65, and p50.p-IKKβ / IKKβ / p-IκBα / IκBα ;PubMed: 29956738Int J OncolFollowing treatment with EMCL at the indicated doses and PDTC (30µM) for 24 h, the protein expression levels of IKKβ, p-IKKβ, IκBα, and p-IκBα were analyzed by western blot analysis.CCR2 / CCR5 / CXCR4 ;PubMed: 10716998Proc Natl Acad Sci U S ADose-response (Left) and time course (Right) of the effect of PDTC on CCR2, CCR5, and CXCR4 mRNA expression. For the dose–response analysis, total RNA was purified from monocytes incubated for 4 h with PDTC at the indicated doses. In kinetic analysis, the total RNA was purified from fresh human monocytes incubated with 50 μM PDTC for the indicated times. Results inAare representative of three separate experiments. 29956738 10716998Immunofluorescencep65 / p50;PubMed: 29956738Int J OncolFollowing treatment with EMCL at the indicated doses and PDTC (30µM) for 24 h, the subcellular localizations of p50 and p65 in 786-0 cells were examined by confocal microscopy analysis(magnification, ×630).29956738

Selleck Chemicals是世界领先的高性能的生命科学产品供应商之一，主要致力于提供MAPK和PI3K/Akt/mTOR等上百个信号通路的高特异性小分子抑制剂。Selleck 产品线补充非常及时，可以提供行业内最新的抑制剂类产品。同时Selleck也是专业的高通量筛选抑制剂分子库、API、天然产物和多肽供应商。