Ube2D1 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Two other homologues of Ube2D1 exist called Ube2D2 and Ube2D3. Ube2D2 is 89% identical to the amino acid sequence of Ube2D1 ad Ube2D3 is 88% identical. Ube2D1 has been linked to cadminum toxicity. It might also play a role in LDL cholesterol receptor ubiquitination in an Idol-dependent fashion.

Additional Information

Product Name: Also Known As: Catalog No.: Size: Molecular Weight: Species: Source: Stock: Concentration: Quality Assurance: Storage: PDF Data Sheet: NCBI RefSeq: Image(s): Shipping Method: References:

6xHis-Ube2D1 (UbcH5A)

USFT; UBCH5; UBC4/5; UBCH5A; E2(17)KB1

C1400

25 µg

16.6 kDa

Human

Bacterial recombinant

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol

See tube label

~95% by SDS-PAGE, see datasheet for gel image

Store at -80°C; avoid multiple freeze-thaw cycles

PDF Datasheet， MSDS

NM_003338

(Click image to enlarge)

Coomassie-stained SDS-PAGELane 1: Molecular weight markersLane 2: 5 µg purified 6xHis-Ube2D1 (UbcH5A)

Dry ice shipping

1. Scheffner M, et al. (1994) Proc Natl Acad Sci USA 91, 8797–8801.2. Huibregtse JM, et al. (1995) Proc Natl Acad Sci USA 92(7), 2563 – 2567.3. Gehrke SG, et al. (2003) Blood 101, 3288 – 3293.4. Tokumoto M, et al. (2011) J Toxicol Sci 36(2), 191 – 200.

Details

Ube2D1 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Two other homologues of Ube2D1 exist called Ube2D2 and Ube2D3. Ube2D2 is 89% identical to the amino acid sequence of Ube2D1 ad Ube2D3 is 88% identical. Ube2D1 has been linked to cadminum toxicity. It might also play a role in LDL cholesterol receptor ubiquitination in an Idol-dependent fashion.Images:(Click image to enlarge) Coomassie-stained SDS-PAGELane 1: Molecular weight markersLane 2: 5 µg purified 6xHis-Ube2D1 (UbcH5A)