Ube2L6 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. One function of this E2 is that it is involved in ubiquitination and degradation of a neuron – specific protein called syntaxin 1. Recently Ube2L6 has been shown to work with the Isg15 E1, Ube1L, to conjugate Isg15 to substrates as well.

Additional Information

Product Name: Also Known As: Catalog No.: Size: Molecular Weight: Species: Source: Stock: Concentration: Quality Assurance: Storage: PDF Data Sheet: NCBI RefSeq: Image(s): Shipping Method: References:

6xHis-Ube2L6

RIG-B; UBCH8; MGC40331

C3001

100 µg

17.8 kDa

Human

Bacterial recombinant

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol

See tube label

~95% by SDS-PAGE, see datasheet for gel image

Store at -80°C; avoid multiple freeze-thaw cycles

PDF Datasheet， MSDS

NM_004223

(Click image to enlarge)

Coomassie-stained SDS-PAGELane 1: Molecular weight markersLane 2: 5 µg purified 6xHis-Ube2L6

Dry ice shipping

1. Kumar S, et al. (1997) J Biol Chem 272, 13548-54.2. Chin LS, et al. (2002) J Biol Chem 277, 35071 – 35079.3. Zhao C, et al. (2004) Proc Natl Acad Sci 101(20), 7578 – 7582.4. Desai SD, et al. (2006) Cancer Res 66(2), 921 – 928.5. Durfee LA, et al. (2008) J Biol Chem 283(35), 23895 – 23902.

Details

Ube2L6 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. One function of this E2 is that it is involved in ubiquitination and degradation of a neuron – specific protein called syntaxin 1. Recently Ube2L6 has been shown to work with the Isg15 E1, Ube1L, to conjugate Isg15 to substrates as well. Images:(Click image to enlarge) Coomassie-stained SDS-PAGELane 1: Molecular weight markersLane 2: 5 µg purified 6xHis-Ube2L6