AT-406 (also called SM-406) is a potent Smac mimetic that inhibits the ubiquitin ligase activity of inhibitors of apoptosis proteins XIAP, cIAP1 and cIAP2 with Ki values of 66.4, 1.9 and 5.1 nM, respectively. AT-406 induces apoptosis of various human cancer cell lines.

Additional Information

Product Name: Also Known As: Catalog No.: Size: Molecular Weight: Species: Source: Stock: Concentration: Quality Assurance: Storage: PDF Data Sheet: NCBI RefSeq: Image(s): Shipping Method: References:

AT-406 (SM-406)

CAS# 1071992-99-8

F7170-5

5 mg

561.71 Da

N/A

Synthetic

Powder

N/A

>98% by HPLC and NMR

Eligible for room temperature shipping. Store at -80°C upon receiving; avoid multiple freeze-thaw cycles after dissolving in DMSO.

Download PDF datasheet

N/A

No

Room temperature shipping

1. Cai Q., et al. (2011) J. Med. Chem. 54, 2714 2. Brunckhorst M. K., et al. (2012) Cancer Biol. Ther., 13, 804

Details

AT-406 (also called SM-406) is a potent Smac mimetic that inhibits the ubiquitin ligase activity of inhibitors of apoptosis proteins XIAP, cIAP1 and cIAP2 with Ki values of 66.4, 1.9 and 5.1 nM, respectively. AT-406 induces apoptosis of various human cancer cell lines.