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Polysciences/DODAP | Polysciences/100mg/14489-100
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Key FeaturesHigh transfection efficiency and low cytotoxicityEfficient delivery of plasmid DNA, siRNA/miRNA, and CRISPR/Cas9 componentsWidely used in nanomedicineFlexible and scalableDODAP (1,2-dioleoyl-3-dimethylammonium-propane) is an ionizable cationic lipid with lower cytotoxicity and high transfection efficiency. DODAP is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7). The electrostatic interactions between DODAP and naturally occurring anionic lipids in endosomal membranes trigger the release of nucleic acid. These interactions promote membrane lytic non-bilayer structures to enable the intracellular delivery of nucleic acid. A common application is in nanomedicine as an ionizable lipid component of nanocarriers (lipid-polymer hybrid nanoparticles, LPNs), widely used to encapsulate bioactive molecules, including mRNA, siRNA, and plasmid DNA as a treatment for diseases.Contact us at [email protected] to know about our cGMP grade DODAP manufactured under 21 CFR part 210,211.
Polysciences, Inc. 成立于1961年,总部位于宾夕法尼亚州沃灵顿,是一家生产研发化学产品的公司。该公司的产品种类已经累计超过3000种,其产品的特点是体积小,附加值高。
Polysciences产品主要包含:
1、 单体和聚合物
2、 微球和粒子(有机、无机、可生物降解、磁珠、荧光素、染料、特异性抗体和蛋白包被颗粒,直径从40nm到10mm)用于核酸提取、蛋白分离和纯化等。
3、 高性能粘合剂、涂料和密封剂
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