Tau promotes the assembly and maintains the structure of microtubules in neuronal cells3,4,5. While the fetal brain contains a single isoform of tau (Tau-352) the adult brain has several isoforms. Tau is both phosphorylated and O-GlcNAcylated6. The normal brain tau contains 2-3 moles of phosphate/mole of the protein. In Alzheimer disease tau is hyperphosphorylated, containing 3-4-fold more phosphate/mole of the protein than the normal tau7,8 and is the major protein subunit of paired helical filaments (PHF) that form the neurofibrillary tangles (NFT). NFT accumulation correlates with the clinical progression of Alzheimers disease. Tau 4G11 (TA-1001) is a rPeptide exclusive Tau Monoclonal Antibody that binds 4 out of the 6 Tau isoforms. It specifically binds Tau-381, Tau-410, Tau-412, and Tau-441 which all contain at least one amino terminal insert.
行业新闻
- 热烈庆祝华拓生物科技有限公司成为rPeptide中国总代理七周年！！
- rpeptide7月份产品报价
- rpeptide常备现货-上海佰晔生物科技中心
- rpeptideA-1008-1 rpeptide供应商
- 抗体 （免疫细胞分泌免疫物质）
- rpeptide
- rPeptide公司代理生物计划 rPeptide总代
- 中国rPeptide公司 rPeptide Inc.中国试剂购买网站
- rPeptide代理，产品目录 美国rPeptide Inc.公司
- 热烈庆祝派克生物成功签约Rpeptide公司中国总代理
- rPeptide中国采购 rPeptide Inc.代理
- rPeptide产品促销 rpeptideA-1008-1
rPeptide/Tau-4G11 Antibody Kit TA-1004/TA-1114-1/50ug
Description Tau is a family of six isoforms, derived from a single gene by alternative mRNA splicing1. They vary in size from 352 to 441 amino acids (36.8 to 45.9 kDa), and differ from one another in having three or four microtubule binding repeats (R) of 31-32 amino acids each, and two, one or none amino terminal inserts (N) of 29 amino acids each2.
