Description P7C3 exerts proneurogenic activity by protecting newborn neurons from apoptosis. Prolonged administration to aged rats impedes neuronal death and preserves cognitive capacity¹. Delays disease progression in G93A-SOD2 mutant mouse model of amyotrophic lateral sclerosis². Blocks MPTP-mediated cell death of dopaminergic neurons in the substantia nigra of adult mice, a model of Parkinson disease³. Restores hippocampal neurogenesis in a mouse model of Down Syndrome⁴. The mechanism of action involves activation of nicotinamide phosphoribosyltransferase (NAMPT) with concomitant increase of intracellular levels of NAD⁵. Active in vivo. Molecular Mass 474.2 Purity >98%