Adipogen/TG101348/SYN-1104-M100/100 mg-蚂蚁淘生物

More Information Product Details Synonyms Product Type Properties Formula MW CAS Purity Chemicals Appearance Solubility Declaration Other Product Data InChi Key Shipping and Handling Shipping Short Term Storage Long Term Storage Use/Stability Documents MSDS Product Specification Sheet Datasheet

SAR-302503

Chemical

C₂₇H₃₆N₆O₃S

524.7

936091-26-8

≥95%

Solid.

Soluble in DMSO or ethanol.

Manufactured by SynKinase.

Target: JAK | Kinase Group: PTK | Substrate: TyrosineClick here for Original Manufacturer Product DatasheetOur product description may differ slightly from the original manufacturers product datasheet.

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AMBIENT

+4°C

-20°C

Stable for at least 2 years after receipt when stored at -20°C.

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TG101348 inhibits JAK2(V617F) with an IC(50) of 3nM. It inhibits erythroid colony formation and also inhibits JAK2-driven STAT5 phosphorylation, cell proliferation and cell survival in JAK2(V617F) cells.Product References

Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera: G. Wernig, et al.; Cancer Cell 13, 311 (2008)

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