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Cosmo/Anti 6-4 Photoproducts (6-4PPs) mAb (Clone 64M-2)/1 Vial/CAC-NM-DND-002
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Application:ICC,ELISA,WB,IP,IHC,FCClonality:MonoclonalHost:MousePurification:AmmoniumSulfateReactivity:AllProlongedexposuretosolarUVrADIationmayresultinharmfulacuteandchroniceffectstotheskin(includingskincancers),eye,andimmunesystem.TheseharmfuleffectsappeartobecloselyrelatedtoUV-inducedDNAdamage.Indeed,UV-inducedDNAdamageplayssignificantrolesincell-cyclearrest,activationofDNArepair,cellkilling,mutation,andneoplastictransformation.ThemajortypesofDNAdamageinducedbysolarUVradiationarecyclobutanepyrimidinedimers(CPDs),(6–4)photoproducts(6-4PPs),andDewarvalenceisomersof6-4PPs(Dewarphotoproducts;DewarPPs)formedbetweenadjacentpyrimidinenucleotidesonthesameDNAstrand.Approximately70-80%ofUV-inducedDNAdamageisCPDsandtheremainingis6-4PPsandDewarisomersof6-4PPs.DewarPPsareproducedbythephotoisomerizationof6-4PPsbyUVradiationaround325nm.InnormalhumancellsthesetypesofDNAlesionsarerepairedbynucleotideexcisionrepair(NER).TobetterstudymoleculareventssurroundingUV-inducedDNAdamageandrepair,Morietal.previouslydevelopedandcharacterizedmonoclonalantibody(mAb)specificforCPDsandmAbspecificfor6-4PPs(1)whileMatsunagaetal.developedandcharacterizedmAbspecificforDewarPPs(2).Threeoftheseantibodies(CPDs:cloneTDM-2;6-4PPs:clone64M-2;DewarPPs:cloneDEM-1)continuetobecitedfrequentlyintheliterature,oftenforuseinELISA.ThisHighSensitivity(6-4)photoproducts(6-4PPs)ELISAKitistheonlycommerciallyavailableELISAutilizinganti-6-4PPsclone64M-2andhasbeenoptimizedforhighsensitivitydetectionof6-4PPsinDNApurifiedfromculturedcellsorfromskinepidermis.ThisELISAdetects6-4PPsfromdipyrimidinesinallDNAsequencecontexts(i.e.,TT,TC,CTandCC).Thus,theavailABIlityandconvenienceofthisELISAKitwillcontributetofurtherunderstandingmolecularmechanismsinvolvedincellularresponsestoUVradiationandDNAdamagewithapplicationsacrossmanyresearchfieldsincludingcancerresearch,photoBIOLOGy,dermatology,ophthalmology,immunology,andcosmeticsscience.References:1)Yamamoto,A.,etal.,DNARepair,6,649-657(2007).2)Matsumoto,M.,etal.,J.CellSci.,120,1104-1112(2007).3)Yasuda,G.,etal.,Mol.Cell.Biol.,27,6606-6614(2007).4)Sugasawa,K.,etal.,Cell121,387-400(2005).5)Nishiwaki,Y.,etal.,J.Invest.Dermatol.122,526-532(2004).6)Imoto,K.,etal.,J.Invest.Dermatol.119,1177-7782(2002).7)Wakasugi,M.,etal.,J.Biol.Chem.,277,1637-1640(2002).8)Kobayashi,N.,etal.,PigmentCellRes.14,94-102(2001).9)Katsumi,S.,etal.,J.Invest.Dermatol.117,1156-1161(2001).10)Otoshi,E.,etal.,CancerRes.60,1729-1735(2000).11)Nakagawa,A.,etal.,J.Invest.Dermatol.110,143-148(1998).12)Kobayashi,N.,etal.,J.Invest.Dermatol.110,806-810(1998).13)Komatsu,Y.,etal.,NucleicAcidsRes.25,3889-3894(1997).14)Nakane,H.,etal.,Nature377,165-168(1995).15)Todo,T.,etal.,Nature361,371-374(1993).16)Kobayashi,N.,etal.,J.Invest.Dermatol.101,685-689(1993).17)Potten,C.S.,etal.,Int.J.Radiat.Biol.63,313-324(1993).18)Matsunaga,T.,etal.,Photochem.Photobiol.54,403-410(1991).19)Mori,T.,etal.,Photochem.Photobiol.54,225-232(1991).Morethan200papersusingTDM-2and64M-2antibodieshavebeenpublishedsofar.
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