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Synaptic Systems(SYSY)/Abeta 43 - 218 903/218 903

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Visualizesubcellularstructuresdirectlyandnoninvasivelybyfluorescencemicroscopy.Withthesevectors,youcanstudycytoskeletalandorganellestructureandfunctioninlivingcells,inrealtime,andwithoutchemicalstaining.Youcanmonitorthelocationofaproteinofinterestrelativetoagivensubcellularstructurebylabelingboththeproteinandthestructurewithseparatefluorescentproteins.Ready-madelentiviralparticlesarealsoavailableforthisapplication.Visualizesubcellularstructuresdirectlyandnoninvasivelybyfluorescencemicroscopy.Withthesevectors,youcanstudycytoskeletalandorganellestructureandfunctioninlivingcells,inrealtime,andwithoutchemicalstaining.Youcanmonitorthelocationofaproteinofinterestrelativetoagivensubcellularstructurebylabelingboththeproteinandthestructurewithseparatefluorescentproteins.Ready-madelentiviralparticlesarealsoavailableforthisapplication.Thesubcellularlocalizationvectorsencodefusionsoffluorescentproteinvariantsandlocalizationsignalsorsubcellularstructuralproteins,whichtargetthefluorescentproteintoaspecificorganelleorsubcellularstructure.Thevectorsareavailableinavarietyoforganelle-andCytoskeleton-targetedcolorvariants.Theyareidealformultiplexlabelingexperiments.PhotoactivatablemCherryvectorsPAmCherryisaphotoactivatablemutantofmCherrythatisnonfluorescentuntilitisexposedto350–400nmlight.Byselectingwhichcellularregionstoactivate,youcantrackorganellesagainstadarkbackground.PAmCherrysubcellularlocalizationvectorsareavailablethattargetPAmCherrytothecellmembrane,mitochondria,actin,ortubulin.ObservephotoactivatedPAmCherrywiththesamefiltersetsusedforotherredfluorescentproteins,suchasDsRedvariantsandmCherry.Lenti-XActinDynamicsMonitoringKitThiskitisdesignedtomonitorthehighlydynamicbehavioroftheactinfilamentsysteminlivecells.ThekitincludeslentiviralvectorsencodingactinfusionstoDD-AcGFP1(green,destABIlized)andmCherry(red),andtheDD"sstabilizingligandShield1.DD-AcGFP1-Actiniscontinuouslytargetedfordegradationinthecellbytheproteasomesunlessthecellsareculturedinmediumcontainingthestabilizingligand,Shield1.Bycontrast,mCherry-Actin(whichdoesnotcontaintheDD)hasnormalstabilityuponexpressionandisconstitutivelypresentinthecell.AddingandremovingShield1createsapulse-chase-likesetofconditionswhichallowyoutomonitorpolymerizationofactinmonomersasnewlysynthesizedDD-AcGFP1-ActinthatisstabilizedasShield1(green)isintegratedintotheexisting(red)mCherry-Actinactinfilamentnetwork.AutophagysensorvectorpAutophagSENSEisamammalianexpressionvectorthatallowsyoutomonitortheprocessofautophagy.pAutophagSENSEencodesafusionofthegreenfluorescentproteinAcGFP1andtheratLC3protein.Incellsnotundergoingautophagy,theAcGFP1-LC3fusionproteinisevenlydistributedinthecytoplasmofatransfectedcell.However,ifacellisundergoingautophagyviatheformationofautophagosomes,theAcGFP1-LC3fusionproteinisincorporatedintoautophagosomes.Thisprocesscanbemonitoredbyfollowingtheredistributionofthegreenfluorescentfusionproteinfromthecytosoltotheformingautophagosomes.Thereadoutisachangefromanevencytosolicdistributionofgreenfluorescenceincellstoapunctatepatternrepresentingtheformingautophagosomes.pAutophagSENSEsavesyoumoneycomparedtootherautophagydetectionsystems,becauseitisvector-based—notaconsumableyouhavetobuyoverandoveragain. More Less

SYSY我们的“隔壁”合作伙伴公司NanoTag Biotechnologies专门研究基于单域抗体的亲和试剂（“标签”），用于生物化学和基于荧光的应用。
他们提供亲和树脂，标签特异性FluoTags和用于各种免疫测定（ICC，IHC，IHC-P，WB等）的辅助试剂。
Synaptic Systems在全球范围内分销NanoTag产品组合。
可以轻松设置定制项目来开发定制的单域抗体。

在临床神经科学系谢汉内洛尔·埃伦赖希教授在哥廷根和突触系统的MPI为实验医学已经成功地进行了多次联合研究项目。我们非常感谢他们在实验设置中验证抗体的贡献。

在分子神经生物学系尼尔斯博泽教授在哥廷根的MPI用于实验医学已经突触系统自成立以来，紧密的合作伙伴。我们的几种抗体是在他们的实验室中开发的。

位于莱比锡的Paul Flechsig脑科学研究所的 WolfgangHärtig教授实验室是我们最重要的外部验证合作伙伴之一，在组织学应用方面拥有丰富的专业知识。