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Monoclonal Antibody

5F6

Mouse IgG1κ

ACR-modified keyhole-lympet hemocyanine.

Immunohistochemistry: Recommended concentration is 0.5-1μg/mL on paraffin sections.

AllHuman

Recognizes ACR-modified proteins (especially FDP-lysine type derivatives).

Protein A purified.

Frozen liquid. Contains 10mM PBS, 0.1% NaN3 and 0.5% BSA.

Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.

Manufactured by JaICA.

BLUE ICE

+4°C

-20°C

Avoid freeze/thaw cycles.

Stable for at least 3 years after receipt when stored at -20°C.

No

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Acrolein (ACR) is a representative carcinogenic aldehyde found ubiquitously in the environment and formed endogenously through oxidation reactions, such as lipid peroxidation and myeloperoxidasecatalyzed amino acid oxidation. ACR is highly reactive aldehyde and reacts with lysine residue in protein. The reaction with ACR and lysine residue leads to the formation of numerous numbers of adducts, such as formyl-dehydropiperidino-lysine (FDP-lysine) type derivative.Product References

Protein-bound acrolein: Potential markers for oxidativestress: K. Uchida, et al.; PNAS 95, 4882 (1998)

Protein-bound acrolein: A novel markers of oxidativestress in Alzheimers Disease: Y. Noel, et al.; J. Neurochem. 72, 751 (1999)