signalchemLifesciences 激酶研究SignalChem Lifesciences Corporation ( SLC )公司总部位于加拿大不列颠哥伦比亚，是激酶研究领域的企业，其两大核心产品系列为生物试剂及研究服务与药物研发服务部。生物试剂及研究服务（SignalChem Pharmaceuticals Inc）始于2004年，致力于研发和生产生物医药研究和药物研发领域的激酶产品，目前拥有的激酶/表观遗传相关酶类及其检测试剂产品超过2000种，覆盖几乎所有激酶靶点以及表观遗传研究相关酶类，以及多种信号蛋白相关产品。同时，为辅助检测激酶及临床疾病和个体化治疗，SignalChem还在生物标志物及诊断试剂盒领域有着数十年的积淀，拥有强大和丰富的相关产品。药物研发服务部致力于寻找新的小分子激酶抑制剂，并用于临床治疗。凭借公司丰富的激酶特异性小分子复合物资源库，以及公司在激酶研究领域强大研究团队和丰富研究经验，SLC在以激酶及其通路为靶点的药物设计、研发和生产具有独特优势，目前公司已拥有大量的以激酶为靶点的小分子抑制剂产品，可用于研究各种肿瘤等疾病。蛋白激酶是联结所有细胞活动的中枢，通过过表达/过度激活及突变蛋白激酶可导致机体功能异常进而引发疾病，因此靶向激酶的药物有着重要的临床应用价值。蛋白激酶家族是仅次于G蛋白偶联受体家族的第二大药物靶点，目前已发现约518种野生型的激酶族以及与其相关的临床突变案例，有超过30种FDA认证的激酶抑制剂。凭借着多年来以激酶为核心的细胞信号相关产品研发积累，以及为科研院所及制药企业科研服务经验，SignalChem在抑制激酶活性的药物领域处于水平，公司不仅拥有zui大的且不断成长的活性激酶及突变激酶产品线，以及可在多个检测平台实施的激酶活性检测试剂盒，而且不断与多个大型制药企业和研究院所广泛合作，公司的主要产及服务包括：1、凭借公司强大的科研力量和经验，SignalChem推出的 Kinome Search Engine 激酶筛选系统，可对每一个激酶族中的单个激酶做出检测，从而辅助和加快激酶药物的研发。2、 Kinome Search Engine 激酶筛选系统不仅可辅助设计激酶药物，还可进一步研究人类激酶族的功能和机制，加深对未知激酶的认识，寻找更多的药物靶点，（目前认证的药物仅仅有少于5%是以已知的激酶通路为靶点，因此激酶通路作为药物靶点有着巨大的潜力和价值）。3、SignalChem公司拥有激酶相关临床突变数据库，在研究疾病复发和抗药领域的核心问题时有着的优势，可以更为有效地协助制药企业进行药物研发。除了药物研发方面的优势，SignalChem还在生物标志物及诊断试剂盒领域有着数十年的积淀，拥有强大和丰富的相关产品。目前SLC公司的产品覆盖了几乎所有细胞内激酶相关通路，包括AKT/PKB通路、ERK/MAPK通路、JAK/STAT通路、JNK/SAPK通路、NfkB通路、p38通路、PKA/PKC通路、WNT信号通路等，适用于血管再生、凋亡和自噬、肿瘤、心血管疾病、细胞周期、细胞应激、胞内酪氨酸激酶、炎症、浸润和转移、脂质激酶、代谢性疾病、神经生物学、磷酸酶/磷酸二酯酶、受体酪氨酸激酶、Ser/Thr激酶等研究领域。主要产品有：一、蛋白酶类产品系列1、高活性乙酰转移酶品名货号种属标记类型表达系统氨基序列基因号KAT2A (GCN5), ActiveK311-381GHumanGST tagSf9 insect cells323-endNM_021078KAT2B (PCAF), ActiveK311-381BGHumanGST tagSf9 insect cells431-endNM_003884KAT3A (CREBBP), ActiveK312-381GHumanGST tagSf9 insect cells1319-1710NM_004380KAT5 (TIP60), ActiveK314-380GHumanGST tagSf9 insect cellsFull LengthNM_006388KAT6B (MYST4), ActiveK315-381BGHumanGST tagSf9 insect cells431-endNM_012330KAT7 (MYST2), ActiveK316-380GHumanGST tagSf9 insect cellsFull LengthNM_0070672、高活性精氨酸脱亚氨酶品名货号种属标记类型表达系统氨基序列基因号PAD Cocktail, ActiveP312-37C---Full Length-3、高活性GTP/ATP酶品名货号种属标记类型表达系统氨基序列基因号CDC42, ActiveC108-310GHHumanGST/HisE.coliFull lengthNM_001791GNAI1, ActiveG121-310GHumanGST tagE.coli2-endNM_002069GNAI2, ActiveG122-310GHumanGST tagE.coli2-endNM_002070GNAI3, ActiveG123-310GHumanGST tagE.coli2-endNM_006496GNAS, ActiveG127-310GHumanGST tagE.coliFull lengthNM_000516HRAS1 (Mature form), ActiveR105-310HHumanHis tagE.coli2-186NM_005343KRAS (Mature form), ActiveR106-310HHumanHis tagE.coli2-186NM_033360NRAS (Mature form), ActiveR107-310HHumanHis tagE.coli2-186NM_002524RAC1, ActiveR103-310GHumanGST tagE.coliFull lengthNM_006908RAC2, ActiveR104-310HHumanHis tagE.coliFull lengthNM_002872RAC3, ActiveR102-310HHumanHis tagE.coliFull lengthNM_005052RhoA (Mature form), ActiveR144-310HHumanHis tagE.coli1-190NM_001664RhoC (Mature form), ActiveR144-310CHHumanHis tagE.coli1-190NM_175744RhoD (Mature form), ActiveR144-310DHHumanHis tagE.coli1-207BC001338VCP, ActiveV116-310GHumanGST tagSf9 insect cellsFull lengthNM_0071264、高活性组蛋白去乙酰化酶品名货号种属标记类型表达系统氨基序列基因号HDAC1, ActiveH83-30GHumanGST tagSf9 insect cellsFull LengthNM_004964HDAC10, ActiveH92-31GHumanGST tagSf9 insect cells1-482NM_032019HDAC11, ActiveH93-30GHumanGST tagSf9 insect cellsFull LengthNM_024827HDAC2, ActiveH84-30GHumanGST tagSf9 insect cellsFull LengthNM_001527HDAC3, ActiveH85-30GHumanGST tagSf9 insect cellsFull LengthNM_003883HDAC3/NCOR2, ActiveH85-38GHumanGST tagsSf9 insect cellsHDAC3 (full-length)/NCOR2 (237-489)NM_003883HDAC4, ActiveH86-31GHumanGST tagSf9 insect cells612-endNM_006037HDAC5, ActiveH87-31GMouseGST tagSf9 insect cells617-endBC060609HDAC6, ActiveH88-30GHumanGST tagSf9 insect cellsFull LengthBC069243HDAC7, ActiveH89-31GHumanGST tagSf9 insect cells501-endNM_015401HDAC8, ActiveH90-30HHumanHis tagSf9 insect cellsFull LengthBC0504335、活性突变激酶（共计253种）品名货号种属标记类型表达系统氨基序列基因号ABL1 Mutant (E255K), ActiveA03-12BGHumanGST tagSf9 insect cells27-end (E255K)NM_005157ABL1 Mutant (E255V), ActiveA03-12HHHumanHis tagSf9 insect cells27-end (E255V)NM_005157ABL1 Mutant (F317I), ActiveA03-12JGHumanGST tagSf9 insect cells27-end (F317I)NM_005157ABL1 Mutant (F317L), ActiveA03-12IGHumanGST tagSf9 insect cells27-end (F317L)NM_005157ABL1 Mutant (G250E), ActiveA03-12CGHumanGST tagSf9 insect cells27-end (G250E)NM_005157ABL1 Mutant (H396P), ActiveA03-12LGHumanGST tagSf9 insect cells27-end (H396P)NM_005157ABL1 Mutant (M351T), ActiveA03-12KGHumanGST tagSf9 insect cells27-end (M351T)NM_005157ABL1 Mutant (Q252H), ActiveA03-12FGHumanGST tagSf9 insect cells27-end (Q252H)NM_005157ABL1 Mutant (T315I), ActiveA03-12DGHumanGST tagSf9 insect cells27-end (T315I)NM_005157ABL1 Mutant (V299L), ActiveA03-12MGHumanGST tagSf9 insect cells27-end (V299L)NM_005157ABL1 Mutant (Y253F), ActiveA03-12EGHumanGST tagSf9 insect cells27-end (Y253F)NM_005157ABL1 Mutant (Y253H), ActiveA03-12GHHumanHis tagSf9 insect cells27-end (Y253H)NM_005157AKT1 Mutant (E17K), ActiveA16-12GHumanGST tagSf9 insect cellsFull length (E17K)NM_005163AKT2 Mutant (E17K), ActiveA17-12GHumanGST tagSf9 insect cellsFull length (E17K)NM_001626AKT2 Mutant (R274H), ActiveA17-12BGHumanGST tagSf9 insect cellsFull length (R274H)NM_001626AKT3 Mutant (E17K), ActiveA18-12GHumanGST tagSf9 insect cellsFull Length (E17K)NM_005465AKT3 Mutant (G171R), ActiveA18-12BGHumanGST tagSf9 insect cellsFull length (G171R)NM_005465ALK Mutant (C1156Y), ActiveA19-12DGHumanGST tagSf9 insect cells1060-end (C1156Y)NM_004304ALK Mutant (F1174L), ActiveA19-12EGHumanGST tagSf9 insect cells1060-end (F1174L)NM_004304ALK Mutant (F1174S), ActiveA19-12FGHumanGST tagSf9 insect cells1060-end (F1174S)NM_004304ALK Mutant (G1202R), ActiveA19-12HGHumanGST tagSf9 insect cells1060-end (G1202R)NM_004304ALK Mutant (G1269A), ActiveA19-12JGHumanGST tagSf9 insect cells1060-end (G1269A)NM_004304ALK Mutant (G1269S), ActiveA19-12KGHumanGST tagSf9 insect cells1060-end (G1269S)NM_004304ALK Mutant (L1152R), ActiveA19-12CGHumanGST tagSf9 insect cells1060-end (L1152R)NM_004304ALK Mutant (L1196M), ActiveA19-12GGHumanGST tagSf9 insect cells1060-end (L1196M)NM_004304ALK Mutant (R1275Q), ActiveA19-12LGHumanGST tagSf9 insect cells1060-end (R1275Q)NM_004304ALK Mutant (S1206R), ActiveA19-12IGHumanGST tagSf9 insect cells1060-end (S1206R)NM_004304ALK Mutant (T1151M), ActiveA19-12BGHumanGST tagSf9 insect cells1060-end (T1151M)NM_004304ALK Mutant (T1151_L1152insT), ActiveA19-12GHumanGST tagSf9 insect cells1060-end (T1151_L1152insT)NM_004304ALK2 Mutant (PF197_198L), ActiveA06-12FGHumanGST tagSf9 insect cells147-end (PF197_198L)NM_001105ALK2 Mutant (Q207D), ActiveA06-13CGHumanGST tagSf9 insect cells147-end (Q207D)NM_001105ALK2 Mutant (Q207E), ActiveA06-13DGHumanGST tagSf9 insect cells147-end (Q207E)NM_001105ALK2 Mutant (R206H), ActiveA06-12BGHumanGST tagSf9 insect cells147-end (R206H)NM_001105ALK3 Mutant (Q233D), ActiveB04-12BGHumanGST tagSf9 insect cells187-end (Q233D)NM_004329ALK3 Mutant (R486Q), ActiveB04-12CGHumanGST tagSf9 insect cells187-end (R486Q)NM_004329AXL Mutant (R499C), ActiveA34-12BGHumanGST tagSf9 insect cells473-end (R499C)NM_021913BCR-RET Mutant, ActiveR02-19EGHumanGST tagSf9 insect cells1-426 (BCR) - 713-end (RET)BC066122BRAF Mutant (d485-489 P490Y), ActiveB08-12IGHumanGST tagSf9 insect cells381-end or exon 9-18 (d485-489 P490Y)NM_004333BRAF Mutant (G464V), ActiveB08-12JGHumanGST tagSf9 insect cells381-end or exon 9-18 (G464V)NM_004333BRAF Mutant (G469A), ActiveB08-12FGHumanGST tagSf9 insect cells381-end or exon 9-18 (G469A)NM_004333BRAF Mutant (K601E), ActiveB08-12BGHumanGST tagSf9 insect cells416-end (K601E)NM_004333BRAF Mutant (L597V), ActiveB08-12HGHumanGST tagSf9 insect cells381-end or exon 9-18 (L597V)NM_004333BRAF Mutant (R506_K507insVLR), ActiveB08-13CGHumanGST tagSf9 insect cells381-end or exon 9-18 (R506_K507insVLR)NM_0043336、活性激酶该产品系列共包括445种激酶产品，下表仅列部分.品名货号种属标记类型表达系统氨基序列基因号ABL1, ActiveA03-11HMouseHis tagSf9 insect cells27-endNM_009594ABL1, ActiveA03-18HHumanHis tagSf9 insect cells27-endNM_005157ABL2, ActiveA04-11HHumanHis tagSf9 insect cells38-endNM_005158ACK, ActiveA05-11GHumanGST tagSf9 insect cells110-476NM_005781AKT1, ActiveA16-10GHumanGST tagSf9 insect cellsFull LengthNM_005163AKT2, ActiveA17-10HHumanHis tagSf9 insect cellsFull LengthNM_001626AKT2, ActiveA17-10GHumanGST tagSf9 insect cellsFull LengthNM_001626AKT3, ActiveA18-10GHumanGST tagSf9 insect cellsFull LengthNM_0054657、高活脂质激酶品名货号种属标记类型表达系统氨基序列基因号DGKA, ActiveD21-10GHumanGST tagSf9 insect cellsFull lengthNM_001345PI3K (p110 alpha (E545K)/p85 alpha), ActiveP27-152HHumanHis tagsSf9 insect cellsFull lengthNM_006218PI3K (p110 alpha (N345K(/p85 alpha), ActiveP27-122CHHumanHis tagsSf9 insect cellsFull lengthNM_006218PI3K (p110 alpha(E542K)/p85 alpha, ActiveP27-122DHHumanHis tagsSf9 insect cellsFull lengthNM_006218PI3K (p110 alpha/p55 gamma), ActiveP27-102CHHumanHis tagSf9 insect cellsFull lengthNM_006218PI3K (p110 alpha/p85 alpha), ActiveP27-102GHumanGST tagsSf9 insect cellsFull lengthNM_006218PI3K (p110 alpha/p85 alpha), ActiveP27-102HHumanHis tagsSf9 insect cellsFull lengthNM_006218PI3K (p110 alpha/p85 alpha), ActiveP27-182HMouseHis tagsSf9 insect cellsFull lengthNM_008839PI3K (p110 beta/p85 alpha), ActiveP28-102HHumanHis tagsSf9 insect cellsFull lengthNM_006219PI3K (p110 beta/p85 beta), ActiveP28-102BHHumanHis tagsSf9 insect cellsFull lengthNM_006219PI3K (p110 delta/p85 alpha), ActiveP30-102HHumanHis tagsSf9 insect cellsFull lengthNM_005026PI3K (p120 gamma), ActiveP29-102HHumanHis tagSf9 insect cellsFull lengthNM_002649PI4K2A, ActiveP21-102GHumanGST tagSf9 insect cellsFull lengthNM_018425PI4K2B, ActiveP22-102GHumanGST tagSf9 insect cellsFull lengthNM_018323PI4KA, ActiveP31-102GHumanGST tagSf9 insect cellsFull lengthNM_002650PI4KB, ActiveP32-102GHumanGST tagSf9 insect cellsFull lengthBC000029PIK3C2A, ActiveP23-112GHumanGST tagSf9 insect cells299-endNM_002645PIK3C2B, ActiveP24-112BGHumanGST tagSf9 insect cells850-endBC1443428、高活性甲基转移酶品名货号种属标记类型表达系统氨基序列基因号COMT, ActiveC339-381GHumanGST tagSf9 insect cells27-271NM_000754DNMT3A, ActiveD353-380GHumanGST tagSf9 insect cellsFull LengthBC043617DNMT3B, ActiveD353-380BGHumanGST tagSf9 insect cellsFull LengthBC111933DNMT3L, ActiveD353-380CGHumanGST tagSf9 insect cellsFull LengthBC002560DOT1L (KMT4), ActiveD344-381GHumanGST tagSf9 insect cells1-435NM_032482EHMT1 (KMT1D), ActiveE317-381GHumanGST tagSf9 insect cells895-endNM_024757EHMT2, ActiveE318-381GHumanGST tagSf9 insect cells807-endNM_006709LCMT1, ActiveL321-380GHumanGST tagSf9 insect cellsFull lengthNM_016309MLL1 (KMT2A), ActiveM341-381GHumanGST tagSf9 insect cells3738-endNM_005933MLL2 (KMT2D), ActiveM342-381GHumanGST tagSf9 insect cells5317-endNM_003482MLL3 (KMT2C), ActiveM343-381GHumanGST tagSf9 insect cells4689-endNM_1706069、高活性磷酸酶品名货号种属标记类型表达系统氨基序列基因号CDC2, ActiveC04-20GHumanGST tagSf9 insect cellsFull LengthNM_001789CDC25B, ActiveC04-20BGHumanGST tagSf9 insect cellsFull LengthNM_021873CDC25C, ActiveC04-20CGHumanGST tagSf9 insect cellsFull LengthBC019089DUSP22 (MKPX), ActiveD22-20GHumanGST tagE.coliFull LengthNM_020185PP1A, ActiveP13-20GHumanGST tagSf9 insect cellsFull LengthNM_002708PP1B, ActiveP14-20GHumanGST tagSf9 insect cellsFull LengthNM_002709PP2A alpha/PPP2R1A Complex, ActiveP16-20BHHumanHis tagsSf9 insect cellsFull lengthNM_002715PP2Aalpha, ActiveP16-20GHumanGST tagSf9 insect cellsFull LengthNM_00271510、高活性磷酸二酯酶品名货号种属标记类型表达系统氨基序列基因号PDE10A, ActiveP98-31GHumanGST tagSf9 insect cells71-endNM_006661PDE1A, ActiveP89-30HHumanHis tagSf9 insect cellsFull LengthNM_005019PDE1B, ActiveP89-30BGHumanGST tagSf9 insect cellsFull LengthNM_000924PDE1C, ActiveP89-30CGHumanGST tagSf9 insect cellsFull LengthNM_005020PDE2A, ActiveP90-30GHumanGST tagSf9 insect cellsFull LengthNM_002599PDE3A, ActiveP91-31GHumanGST tagSf9 insect cells669-endNM_000921PDE3B, ActiveP91-31BGHumanGST tagSf9 insect cells654-endNM_000922PDE4A, ActiveP92-31GHumanGST tagSf9 insect cells332-endNM_001111307PDE4B, ActiveP92-31BGHumanGST tagSf9 insect cells305-endNM_002600PDE4C, ActiveP92-31CGHumanGST tagSf9 insect cells287-endNM_00092311、高活性蛋白酶品名货号种属标记类型表达系统氨基序列CPB (carboxypeptidase B), ActiveC560-31NRattag-freeYeast cells109-endEK (enterokinase), ActiveE535-31HSwineHis tagYeast cells800-endImmobilized Lys-c, AgaroseL585-31ANBacteriatag-freeE.coli206-473 aaImmobilized Lys-c, SilicaL585-31SNBacteriatag-freeE.coli206-473 aaImmobilized Thrombin, AgaroseT565-31ANHumanNativeImmobilized Trypsin, AgaroseT575-31ANSwinetag-freeYeast cells10-endImmobilized Trypsin, SilicaT575-31SNSwinetag-freeYeast cells10-endKEX2 Protease, ActiveK525-31NYeasttag-freeYeast cells110-660 aaLys-c (lysyl-endopeptidase), ActiveL585-31NBacteriatag-freeE.coli206-473 aa二、抗体产品系列1、亚型特异性抗体品名货号宿主应用Anti-AKT3A18-63RRabbitWBAnti-AMPK alpha 1P47-63RRabbitWBAnti-CAMK1C07-60MMouse, IgG1, 5H8WBAnti-CHK2C48-60MMouse, IgG1, 7F9WBAnti-ERK1M29-60MMouse, IgG1, E32WB, IPAnti-ERK1M29-60BMMouse, IgG1, E19WB, IPAnti-GSK3 alphaG08-63RRabbitWBAnti-GSK3 betaG09-60MMouse, IgG1, 6C2WBAnti-HSP90 betaH36-63RRabbitWB2、偶联修饰的抗体品名货号宿主应用Anti-5-Methylated Cytosine (5-methyl cytosine)C92-67SSheep, IgGWB, IPAnti-Acetylated LysineL95-66RRabbitWB, ELISA, PI, IHC, IFAnti-Acetylated Lysine, Biotin ConjugatedL95-66BRRabbitWB, ELISA, IF, IHC, IPAnti-Acetylated Lysine, FITC ConjugatedL95-66CRRabbitFor direct immunofluorescence assayAnti-Acetylated Lysine, HRP ConjugatedL95-66DRRabbitWB, ELISA, IF, IHC, IPAnti-Methylated Arginine (NG, NG-Di-methyl)A96-67RRabbitWB, ELISA, IF, IHC, IPAnti-Methylated Arginine (NG-Mono-methyl)A95-67RRabbitWB, ELISA, IF, IHC, IPAnti-Methylated Lysine (Tri- epsilon-N-methyl)L95-67RRabbitWB, ELISA, IF, IHC, IP3、磷酸化特异性抗体该产品系列共包括82款磷酸化特异性抗体，下表仅列部分产品，品名货号宿主应用Anti-phospho-14-3-3 beta (Ser58)Y71-365RRabbit, IgGWB, IHCAnti-phospho-4EBP1 (Thr45)E35-365RRabbit, IgGWB, IHCAnti-phospho-AKT1/2/3 (Ser473)A16-65BRRabbit, IgGWB, IHCAnti-phospho-AKT1/2/3 (Thr308)A16-65RRabbit, IgGWB, IHCAnti-phospho-ASK1 (Ser966)M13-65RRabbit, IgGIHCAnti-phospho-ATF2 (Ser112)A10-565RRabbit, IgGIHCAnti-phospho-ATF2 (Ser490 Ser498)A10-565BRRabbit, IgGWB, IHCAnti-phospho-BRCA1 (Ser1423)B87-365RRabbit, IgGIHCAnti-phospho-c-KIT (Tyr721)K06-65RRabbit, IgGWBAnti-phospho-c-KIT (Tyr936)K06-65BRRabbit, IgGIHC4、Primary Antibodies该产品系列共包括279款原初抗体，下表仅列部分产品品名货号宿主应用Anti-4EBP1E35-563RRabbit, IgGWB, ELISA, ICCAnti-ADD1A38-63RRabbitWBAnti-AFXA42-63RRabbitWBAnti-AKT (pan)A16-63RRabbitWBAnti-AKT (pan)A16-63BRRabbitWBAnti-AKT1A16-60MMouse, Monoclonal, 9A4WBAnti-AKT1A16-63CRRabbit, IgGWB, ELISA, IF, IHCAnti-AKT2/3A17-63BRRabbitWBAnti-ALK2A06-63RRabbit, IgGWB, ELISAAnti-ALK4A07-63RRabbit, IgGWB, ELISA5、二抗品名货号宿主应用Anti-Mouse HRPG32-62GGoat PolyclonalWB, ELISAAnti-Rabbit HRPG33-62GGoat PolyclonalWB, ELISA6、Tag标签抗体品名货号宿主应用Anti-DYKDDDDKF51-61MMouse, IgG2b, FG4RWB, ELISA, IP, ISAnti-DYKDDDDKF51-63RRabbitWBAnti-GFPG46-60MMouse, IgG1, GF28RWBAnti-GSTG52-61MMouse, IgG2a, G2RWBAnti-HAH98-61MMouse, IgG3, C10WB, ELISA, IP, ISAnti-HAH98-63RRabbit PolyclonalWB, ELISA, IP, ISAnti-HisH99-61MMouse, IgG2b, EH158WB, ELISA, IP, ISAnti-HisH99-63RRabbitWB, ELISA, IP, ISAnti-MycM86-61MMouse, IgG1, M19WB, ELISA, IP, ISAnti-RFPR46-61MMouse, IgG1, RF5RWBAnti-V5V05-61MMouse, IgG1, V4RRWB, ELISA, IP, IS三、生物制剂产品系列1、表观遗传酶激活剂品名货号CAS 注册号分子式纯度BML-278S35-904CN/FC24H25NO4 98% (TLC)CTPBP07-903586976-24-1C31H43ClF3NO298%ResveratrolS35-904501-36-0C14H12O3 98%SirtActS35-904E839699-72-8C20H25N5O298% (TLC)2、表观遗传酶抑制剂该产品系列共包括33款表观遗传研究酶类的抑制剂，下表仅列部分产品品名货号应用2 -Deoxy-5-fluorocytidineD353-904D不可逆DNA甲基转移酶抑制剂5-AzacytidineD353-904DNA低甲基化试剂AK-7S36-904SIRT2抑制剂APICIDINH83-904BHDAC抑制剂BIX-01294 3HClS344-903Histone甲基转移酶抑制剂BML-210H83-904CHDAC抑制剂C-646K311-903HAT抑制剂ChaetocinK421-904CLy甲基转移酶抑制剂CPTH2K311-903BHAT 抑制剂3、激酶激活剂品名货号CAS 注册号分子式纯度8-pCPT-2-O-Me-cAMP-AMR46-9051152197-23-3C20H21ClN5O8PS 97% (HPLC)AICARP47-900B2627-69-2C9H14N4O5 99% (TLC); NMR (Conforms)4、激酶抑制剂该产品系列共包括80款常用激酶抑制剂，下表仅列部分产品品名货号应用6BIOG08-900GSK3 inhibitorA83-01A09-900ALK inhibitorAAL-993F11-900CVEGF inhibitorAG-1296P12-900PDGFR InhibitorAG-1478E10-900BEGFR inhibitorAG-1517K11-900BTyrosine kinase inhibitor5、磷酸酶抑制剂品名货号CAS 注册号分子式纯度CantharidinP16-902C56-25-7C10H12O4 98% (HPLC)EX-527S35-904F49843-98-3C13H13ClN2O98% (TLC)NSC-663284C04-902383907-43-5C15H16ClN3O3 98%Okadaic acid, free acidP16-90278111-17-8C44H68O13 98% (TLC)6、内参siRNA品名货号beta-Actin Positive Control siRNAA03-911DCy3 Labeled Negative Control siRNAS02-910NFAM Labeled Negative Control siRNAS03-910NGAPDH Positive Control siRNAG13-911BUnlabeled Negative Control siRNAS01-910N7、激酶研究常用siRNA该产品系列共包括782款常用激酶的siRNA，下表仅列部分产品品名货号14-3-3 alpha/beta siRNA Set IY71-91114-3-3 epsilon siRNA Set IY75-91114-3-3 sigma siRNA Set IY86-91114-3-3 theta siRNA Set IY84-91114-3-3 zeta siRNA Set IY92-9114EBP1 siRNA Set IE35-911AATK siRNA Set IA02-911ABL1 siRNA Set IA03-911ABL2 siRNA Set IA04-911ACK siRNA Set IA05-911ACVR2A siRNA SetiA35-911四、信号通路蛋白及酶该产品系列包括目前常用的信号通路蛋白及相关酶类，品种多种多样，包括：乙酰/甲基转移酶系列、适配蛋白系列、凋亡通路系列、精氨酸脱亚氨酶系列、细胞周期蛋白系列、细胞应激及分子伴侣蛋白系列、去乙酰化/甲基化酶系列、二氢嘧啶酶系列、双加氧酶系列、果糖激酶系列、G-蛋白家族产品系列、激酶突变体产品系列、蛋白激酶产品系列、脂质氧化酶系列、微管/肌动蛋白相关蛋白产品系列、磷脂酶C家族产品系列、超氧化物歧化酶产品系列、Tau蛋白及其相关产品系列、转录因子产品系列、泛素蛋白产品系列以及无活性激酶产品系列。五、信号通路相关检测试剂该产品系列包括检测试剂、脂类酶底物、寡氨酸底物、肽底物、蛋白酶底物等产品系列。六、胞外配体蛋白该产品系列包括细胞趋化因子、细胞因子及生长因子（生长因子共134种，下表仅列部分）。品名货号应用IP-10I838-40NCell AssayRANTES (CCL5)R801-40NCell AssaySDF-1S821-40NCell AssayIFN-gammaI837-40NTNF-alphaT860-40NTNF-betaT861-40BGTNFBT861-40NTRAILT880-40NSLC中国代理商上海起发实验试剂有限公司，是专业从事生命科学研究领域产品代理及部分生物产品自主研发，以为科研人员提供高品质科研产品为己任，是您值得信赖的科研伙伴！ （来源：上海起发实验试剂有限公司）关注本网官方微信 随时阅读专业资讯