Enzolifesciences/Lamin A/C monoclonal antibody (4C11)/ALX-804-672-C200/200µg
Product Specification:
| Clone: | 4C11 |
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| Host: | Mouse |
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| Isotype: | IgG2a |
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| Immunogen: | Recombinant human lamin A/C (aa 430-545). |
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| UniProt ID: | P02545 |
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| Species reactivity: | Human, Mouse, RatHamster, Monkey |
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| Crossreactivity: | Does not cross-react with lamin B1 and lamin B2. |
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| Applications: | ICC, IP, WB |
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| Recommended Dilutions/Conditions: | Immunocytochemistry (1:100)Immunoprecipitation (5-10µl/assay)Western Blot (1:2,000-1:5,000)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
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| Formulation: | Liquid. Hybridoma supernatant containing sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Shipped on Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Lamin A is a type V intermediate filament protein, involved in maintaining nuclear shape and structure, transcriptional regulation, nuclear pore positioning and function, and heterochromatin organization. Mutations in lamin A are associated with several genetic degenerative disease, including Hutchinson-Gilford progeria syndrome (HGPS), which is caused by Progerin a truncated version of lamin A. A-type lamins have been described prognostic biomarkers for colorectal cancer, and lamin A (but not lamin C) is a potential adult stem cell biomarker in colonic crypts. |
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