首页 > Bachem > Bachem/Amyloid β-Protein (4-42) ammonium salt/H-7434.0500/0.5 mg

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Bachem/Amyloid β-Protein (4-42) ammonium salt/H-7434.0500/0.5 mg

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Details Aβ 4-42 could be one of the earliest and most prominent Aβ species deposited in AD brain. Sequencing of amyloid plaque cores showed that 64% of the isolated Aβ had a phenylalanine at its N-terminus, and indeed, IP/MS experiments identified Aβ 4-42 as a major Aβ species in AD patients. Additionally, Aβ 4-42 was found to be a component of cotton wool plaques in familial AD patients with the V261I PS1 mutation. Aβ 4-42 was discovered as well in amyloid deposits from vascular dementia and familial Danish dementia patients. These observations indicate that Aβ 4-42 may contribute to the development of multiple CNS diseases. Item Number 4090138 One Letter Code FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA Synonyms Aβ (4-42) Molecular Formula C₁₉₁H₂₉₄N₅₂O₅₃S Relative Molecular Mass 4198.82 CAS Registry Number [157884-72-5] net Source Synthetic Storage Conditions -20 ± 5 °C Areas of Interest Alzheimer's Disease Links / Documents: Peptide Calculator Brochures: Amyloid Peptides Care and Handling of Amyloid Peptides Product citations G. Antonios et al., Acta Neuropathol. Commun., 1, 56 (2013) Y. Bouter et al., Acta Neuropathol., 126, 189 (2013) E.Portelius et al., Acta Neuropathol., 120, 185 (2010) Y. Tomidokoro et al., J. Biol. Chem., 280, 36883 (2005)