Biological Activity (-)-Xestospongin C is a reported inhibitor of IP3-dependent Ca2+ release. Inhibits bradykinin-induced Ca2+ release in PC12 cells and attenuates PHP-induced IL-2 production in Jurkat T cells. Exhibits no effect on ryanodine receptor-mediated Ca2+ release in PC12 cells. Does not interact with the IP3 binding site. Recently shown to be an ineffective antagonist of IP3-evoked Ca2+ release in IP3 receptor expressing DT40 cells. Cell permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations: Showing 1 - 10

No product specific FAQs exist for this product, however you may

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Retinal dissections were performed in HEPES-buffered extracellular solution containing glutamate inhibitor cocktail - 1 umol/L

We used (-)-Xestospongin C (XeC) to block calcium release from endoplasmic reticulum via IP3 channels in presynaptic neurons. As a result, LPI, agonist of GPR55 receptor, failed to induce an increase of neurotransmitter release, since this process is calcium-dependent. As a sequence, after application of XeC there was no augmentation of the amplitude of evoked post-synaptic response in postsynaptic neuron: see image.