MACH 4 is a highly sensitive universal detection system. The MACH 4 system can detect either mouse or rabbit antibodies, and is a two-step universal detection method. MACH 4 is available in a universal (anti-mouse and anti-rabbit) format, labeled with either Horseradish Peroxidase (HRP) or Alkaline Phosphatase (AP). MACH 4 detection consists of two reagents: the secondary, also known as the enhancing reagent, is applied between the primary antibody and micro-polymer reagent. MACH 4 is ideal for use with antibody solutions prepared from concentrates or prediluted antibody solutions. Due to its increased sensitivity, MACH 4 enables a significantly higher dilution of concentrated antibodies compared to other polymer-based detection systems.MACH 4 micro-polymer system incorporates two key technologies:• Enhanced probe to increase sensitivity 10- to 20- fold• Increased density of enzymes bound to tertiaries• 10 – 20 times more sensitive than conventional dextran polymer systems• 20 – 40 times more sensitive for nuclear staining• Suitable to detect mouse specific anti-biotin or antidigoxigenin antibody in in situ hybridization (ISH)• Micro-polymer allows superior specificity/sensitivity, nuclear access and primary antibody dilution• Compatible with automated immunostainers• Compact structure enables 40-fold increase in primary antibody dilution.Compare MACH 4 (L) with leading competitor (R) for ER (1D5) staining. All prices presented are US list price for sale to clients in the Domestic US only. Please see your international distributor for country specific pricing. For a full list of international distributors, click here.