世界*实验材料供应商dianova正式授权上海起发为其中国代理，Dianova在一直是行业的*,一直为广大科研客户提供zui为的产品和服务,上海起发一直秉承为中国科研客户带来的产品，的服务，签约Dianova就是为了给广大科研客户带来更加完善的产品和服务,您的满意将是我们zui大的收获Dianova中国代理,Dianova上海代理，Dianova北京代理，Dianova广东代理，Dianova江苏代理Dianova湖北代理,Dianova天津,Dianova黑龙江代理,Dianova内蒙古代理,Dianova吉林代理,Dianova福建代理,Dianova江苏代理,Dianova浙江代理,Dianova四川代理,Dianova公司为德国的病理免疫组化产品供应商，具备的抗体制备工艺及严格的质控系统，产品在上享有良好的声誉。克隆号为H09的IDH1（isocitrate dehydrogenase 1, 异柠檬酸盐脱氢酶1）鼠单克隆抗体为Dianova公司近期推出的产品之一，此抗体可特异性的检测脑组织肿瘤中IDH1基因的R132H点突变。IDH1基因的第132密码子的杂合突变是II和III级神经胶质瘤（根据WHO的肿瘤学分类）的频发事件。在大约70％的星形胶质细胞瘤和少突神经胶质细胞瘤可发现IDH1基因的R132H点突变。IDH1基因R132H突变在部分脑肿瘤中的频发现象使克隆号为H09的IDH1抗体可高灵敏性和高特异性的用于此类肿瘤的鉴别诊断中：如从原发性胶质母细胞瘤中区分出间变性星形细胞瘤、从毛细胞型星形细胞瘤或室管膜（细胞）瘤中区分出弥漫性星形细胞瘤（WHO分类II级），也可以用于具有IDH1突变的肿瘤细胞浸润前沿的与反应性神经胶质增多症的区分。因此，由于其高灵敏性和高特异性，此抗体在脑部肿瘤的分类分级中以及在检测单一或少量浸润肿瘤细胞时是非常有用的。DIA-310 Anti-CD31 (Ms) aus Ratte (Klon: SZ31) f r Paraffingewebe aus Maus 500 µlArt.-Nr. DIA-310Spezifit tCD31 (PECAM-1)Spezies-Reaktivit tSchwein MausWirtsspezies RatteIsotypIgG2aKlonSZ31Klonalit t (Mono-/Polyklonal) monoklonalAnwendung Immunhistochemie (IHC)Immunhistochemie (Paraffingewebe)Gefrierschnitte (IHC-F)Western BlotKonjugation unkonjugiertFormat Lyophilisatgereinigter Antik rper (aus Kultur berstand)Produktlinie / Thema Angiogenese CD-Marker ImmunhistochemieZweckbestimmungnur f r ForschungszweckeSuchcode DIA310Hersler / MarkedianovaDIA-310 Anti-CD31 (Ms) aus Ratte (Klon: SZ31) f r Paraffingewebe aus Maus 500 µlArt.-Nr.DIA-310Spezifit tCD31 (PECAM-1)Spezies-Reaktivit tSchweinMausWirtsspeziesRatteIsotypIgG2aKlonSZ31Klonalit t (Mono-/Polyklonal)monoklonalAnwendungImmunhistochemie (IHC)Immunhistochemie (Paraffingewebe)Gefrierschnitte (IHC-F)Western BlotKonjugationunkonjugiertFormatLyophilisatgereinigter Antik rper (aus Kultur berstand)Produktlinie / ThemaAngiogeneseCD-MarkerImmunhistochemieZweckbestimmungnur f r ForschungszweckeSuchcodeDIA310Hersler / MarkedianovaReactivityAntibody clone SZ31 is the first antibody which reacts specifically with murine CD31 in formalin-fixed paraffin-embedded tissue sections.CD31, also known as PECAM-1 (Plaet Endothelial Cell Adhesion Molecule-1) is expressed constitutively on the surface of embryonic and adult endothelial cells. It is also expressed on cell surfaces of monocytes, neutrophils, plaets and certain T-cell subsets. It has been detected on bone marrow-derived hematopoetic stem cells and embryonic stem cells.CD31 is a 130kDa integral membrane glycoprotein and as a member of the immunoglobulin superfamily involved in the mediation of cell-to-cell adhesion. CD31-mediated endothelial cell-cell interactions play a major role in angiogenesis. Studies have shownCD31to be asuperior marker in human angiogenesis, which reportedly predicts tumor recurrence. Pathophysiologicalstudies of CD31 in murine model systems had limitationsbecause standard formalin-fixed sections were excluded. Theclone SZ31 eliminates these restrictionsby allowing high quality immunohistochemical analysis of standard formalin-fixed paraffin sections in mice.Immunohistochemistry of mouse CD31 (PECAM-1) in formalin-fixed paraffin-embedded tissue sectionsThe monoclonal antibody clone SZ31 reacts specifically with endothelial cells in vessels and capillaries of:aortaaortic originendocardiumsmall intestinesmall intestinecolonbrainlymph nodesbone marrowmesenterial vesselskidneypancreas(pictures courtesy of Prof. Dr. Robert Klopfleisch, Institute of Pathology, Department of Veterinary Pathology, Berlin, Germany)LungMuscleSpinalLiverAdenocarcinomaAdenocarcinoma(pictures courtesy of Prof.Dr.H.Stein, Institute of Pathology, Charit Campus Benjamin Franklin, Berlin, Germany)Western blot analysisImmunoblot of extracts from murine lung, J558L cells and m-Lend cells using CD31 rat monoclonal antibody clone SZ31 (DIA-310 1:5.000) and goat anti-rat-HRP antibody (1:10.000).Lane:J558 cells (CD31-), 25 g lysatemurine lung, 25 g lysateblankm-Lend cells (CD31+), 12.5 g lysateReferencesH lscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, Wielockx B, Breier G, Katschinski DM, Zieseniss A.Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury.J.Biol.Chem. 286: 11185-11194, 2011Kr ger C, Vijayaraj P, Reuter U, Windoffer R, Simmons D, Heukamp L, Leube R, Magin TM. Placental vasculogenesis isregulated by keratin-mediated hyperoxia in murine decidual tissues. Am.J.Pathol. 178(4): 1587-1590, 2011Jiang J, Thyagarajan-Sahu A, Krchn k V, Jedinak A, Sandusky GE, et al. NAHA, a Novel Hydroxamic Acid-Derivative,Inhibits Growth and Angiogenesis of Breast Cancer In Vitro and In Vivo. PLoS ONE 7(3): e34283, 2012Copeland BT, Bowman MJ, Ashman LK. Genetic Ablation of the Tetraspanin CD151 Reduces Spontaneous MetastaticSpread of Prostate Cancer in the TRAMP Model. Mol Cancer Res. 11(1):95-105, 2013Agliano A, Martin-Padura I, Marighetti P, Gregato G, Calleri A, Prior C, Redrado M, Calvo A, Bertolini F. Therapeutic effectof lenalidomide in a novel xenograft mouse model of human blastic NK cell lymphoma/blastic plasmacytoid dendriticcell neoplasm. Clin Cancer Res. 1;17(19):6163-73, 2011Ferretti E, Montagna D, Di Carlo E, Cocco C, Ribatti D, Ognio E, Sorrentino C, Lisini D, Bertaina A, Locali F, Pistoia V,Airoldi I. Absence of IL-12R 2 in CD33(+)CD38(+) pediatric acute myeloid leukemia cells favours progression inNOD/SCID/IL2R C-deficient mice. Leukemia 26(2):225-35,2012相关产品信息如下：Antibodies/MouseHistology-IHCFFPE货号品名规格DIA-303Anti-CD3(Ms,FFPE)fromRat(Clone:HH3E)0.5mlDIA-303-MAnti-CD3(Ms,FFPE)fromRat(Clone:HH3E)0.1mlDIA-310Anti-CD31(Ms,FFPE)fromRat(Clone:SZ31)0.5mlDIA-310-MAnti-CD31(Ms,FFPE)fromRat(Clone:SZ31)0.1mlDIA-404Anti-CD4(Ms,FFPE)fromRat(CloneGHH8)0.2mlDIA-404-MAnti-CD4(Ms,FFPE)fromRat(CloneGHH8)0.05mlDIA-808Anti-CD8a(Ms,FFPE)fromRat(CloneGHH8)0.2mlDIA-808-MAnti-CD8a(Ms,FFPE)fromRat(CloneGHH8)0.05ml我们公司zui大优势是强大的采购，1：基本什么都能进口，血清，抗体，耗材，还有部分限制进口的，2：货品全，现经营过700多个品牌，基本所有生物试剂耗材都可以进口，特别是冷偏的产品那就更有优势，3：提供加急服务，一般1-2周到货，超过时限加急费全免4：价格公道，绝大部分价格有优势，当然不能保证100%产品都是,因为意味着没有服务.5：良好的信誉，大部分客户我们提供货到付款服务，客户包括清华，北大交大复旦，中山等100多所大学，ROCHE，阿斯利康，国药，fisher等500多家公司6：我们还是Santa,Advanced Biotechnologies Inc,Dianova,bangs,BBInternational,crystalchem,dianova,FD Neurotechnologies,Inc. Dako,Inc, GePromegaridege,DianovaBiotechnology GmbH; iduron,Innovative Research of America, Ludger, neuroprobe,Dianova, Polysciences,prospecbi, QA-BIO,quickzyme,FULLERLABS,INC,sterlitech；sysy,TriLink BioTechnologies,Inc；worthington-biochem,zyagen等几十家国外公司授权代理。7：我们还是invitrogen,qiagen,Midland BioProducts Corporationam,sigma;neb,roche,merck, rnd,BD, GE,pierce,BioLegend等知名*批发，欢迎合作。 关注本网官方微信 随时阅读专业资讯