Enzolifesciences/LAMP1 monoclonal antibody (Ly1C6)/ADI-VAM-EN001-D/50µg
Product Specification:
| Alternative Name: | Lysosomal-associated membrane protein 1 |
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| Clone: | LY1C6 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Rat liver lysosomal membrane preparation. |
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| UniProt ID: | P14562 |
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| GenBank ID: | M34959 |
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| Species reactivity: | Human, RatHamster |
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| Applications: | ICC, IF, IP, WBElectron microscopy |
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| Recommended Dilutions/Conditions: | Immunocytochemistry (1:100)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~120kDa by Western blot. |
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| Purity Detail: | Protein G affinity purified. |
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| Formulation: | Liquid. In PBS containing 50% glycerol and 0.09% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Lysosome-associated membrane proteins (LAMP1 and LAMP2) are type I integral membrane protein that are transported from the trans-Golgi network to endosomes and then lysosomes. Following activation of platelets, T-cells, neutrophils, or endothelium, LAMP1 and LAMP2 are expressed on the cell surface. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and loss of LAMP2 expression is associated with impaired autophagy observed in Danons disease. |
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