首页 > Medimabs > Medimabs/Anti-GluR2 (GluA2)-phosphoserine 880/MM-0200 -- Anti-GluR2 -phosphoserine 880 Monoclonal Antibody/100 µg

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Medimabs/Anti-GluR2 (GluA2)-phosphoserine 880/MM-0200 -- Anti-GluR2 -phosphoserine 880 Monoclonal Antibody/100 µg

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MM-0200--Anti-GluR2-phosphoserine880MonoclonalAntibody

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.content-left {float:left;font-weight:bold;} .content-right {float:right;}Product NameAnti-GluR2 (GluA2)-phosphoserine 880 HostMouse DataSHEET View Datasheet (PDF) IsotypeIgG ConjugationUnconjugated ReactivityThe antibody specifically binds to Glutamate Receptor 2-phosphoserine-880 SpecificityRat; other species not tested. Storage BufferLyophilized antibody can be kept at 4ÂºC for up to 3 months and should be kept at -20ÂºC for long-term storage. Format100 µg BackgroundIn the nervous system, much of the fast excitatory transmission is sent by AMPA receptors, tetrameric ionotropic receptors that may be composed of four types of glutamate receptor subunits, formerly known as GluR1-4, and now often abbreviated as GluA1-4. The composition of receptor subunits determine the trafficking of the AMPA receptor in and out of the synapse, which can in turn cause changes in synaptic plasticity, including regulation of long term potentiation (LTP) and long term depression (LTD). Phosphorylation of GluA2 at serine 880 has been shown to disrupt interactions with the glutamate receptor interacting protein (GRIP), thus regulating receptor stability at the synapse.

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