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Medimabs/KDEL Receptor Mouse Monoclonal Antibody (KD10-2)/MM-0220 -- anti-KDEL Receptor/100 µg

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MM-0220--anti-KDELReceptor

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.content-left {float:left;font-weight:bold;} .content-right {float:right;}Product NameKDEL Receptor Mouse Monoclonal Antibody (KD10-2) HostMouse ClonalityMonoclonal Clone IDKD10-2 DataSHEET View Datasheet (PDF) IsotypeIgG ConjugationNone ReactivityHuman, rat, canine, monkey, bovine SpecificityC-terminal Format100 µg BackgroundThe KDEL receptor is a seven-transmembrane-domain protein responsible for the retrieval of soluble ER (endoplasmic reticulum) luminal proteins bearing a C-terminal KDEL sequence (Lys-Asp-Glu-Leu) from the Golgi apparatus of mammals or a His-Asp-Glu-Leu sequence (HDEL) in S. cerevisiae. The KDEL receptor exhibits extensive sequence homology to the yeast protein Erd2p (also known as the HDEL receptor). Retention of the soluble ER proteins requires interaction between the KDEL sequences with the corresponding KDEL receptor. Once KDEL proteins reach the Golgi complex, they are recognized by the KDEL receptor and transported in coat protein (COPI)-coated vesicles back to the ER. Recent studies have demonstrated that while bound to certain partners, the KDEL receptor can trigger the activation of Src family kinases on the Golgi complex.

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