首页 > Medimabs > Medimabs/Spliceosome-associated protein 62, SAP 62, Mouse Antibody (4G8)/MM-0223 -- anti-SAP 62/100 µg

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Medimabs/Spliceosome-associated protein 62, SAP 62, Mouse Antibody (4G8)/MM-0223 -- anti-SAP 62/100 µg

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MM-0223--anti-SAP62

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.content-left {float:left;font-weight:bold;} .content-right {float:right;}Product NameSpliceosome-associated protein 62, SAP 62, Mouse Antibody (4G8) HostMouse ClonalityMonoclonal Clone ID4G8 DataSHEET View Datasheet (PDF) IsotypeIgG1 ConjugationNone ReactivityHuman, monkey, rat SpecificityC-terminal Format100 µg BackgroundThe spliceosome is an extremely complex macromolecular machine responsible for premRNA splicing. It assembles five U-rich small nuclear RNAs (snRNAs) and over 200 proteins in a highly dynamic fashion. The spliceosome-associated protein 62 (SAP 62, also known as splicing factor 3A subunit 2) is heterotrimer which includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein.

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