首页 > Medimabs > Medimabs/AIF (Human Apoptosis Inducing Factor) Mouse Monoclonal Antibody (3C11) - Purified/MM-0208-P -- anti-Human AIF/1

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Medimabs/AIF (Human Apoptosis Inducing Factor) Mouse Monoclonal Antibody (3C11) - Purified/MM-0208-P -- anti-Human AIF/1

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MM-0208-P--anti-HumanAIF

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.content-left {float:left;font-weight:bold;} .content-right {float:right;}Product NameAIF (Human Apoptosis Inducing Factor) Mouse Monoclonal Antibody (3C11) - Purified HostMouse ClonalityMonoclonal Clone ID3C11 DataSHEET View Datasheet (PDF) IsotypeIgG1 ConjugationNone ReactivityHuman, mouse SpecificityFull length Format100 µg BackgroundThe Apoptosis Inducing Factor (AIF) is a 67 kDa protein that contains a mitochondrial localization signal in the N-terminus and NADH oxidase activity in its C-terminal region. AIF is a nuclear-encoded mitochondrial protein which initiates a caspase-independent pathway of apoptosis by triggering chromatin condensation and DNA fragmentation. Upon apoptotic signaling, AIF is released from the damaged mitochondria, after which it enters the cytosol and finally the nucleus where it causes chromatin condensation and DNA fragmentation. AIF also has a role in the mitochondrial respiratory chain as well as in metabolic redox reactions.

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