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Medimabs/High-voltage calcium channels, beta-3 subunit Mouse Monoclonal Antibody (7D1)/MM-0209 -- anti-High-voltage cal

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MM-0209--anti-High-voltagecalciumchannels,beta-3subuni

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.content-left {float:left;font-weight:bold;} .content-right {float:right;}Product NameHigh-voltage calcium channels, beta-3 subunit Mouse Monoclonal Antibody (7D1) HostMouse ClonalityMonoclonal Clone ID7D1 DataSHEET View Datasheet (PDF) IsotypeIgG1 ConjugationNone ReactivityMouse Specificitybeta3 subunit Format100 µg BackgroundVoltage-gated ion channels (VDIC) are a class of transmembrane ion channels that are activated by changes in electrical potential difference near the channel. Voltage-dependent calcium channels (VDCC) are multi-subunit membrane complexes that allow depolarization-induced calcium influx into cells. The opening and closing of these channels by depolarizing stimuli allows calcium ions to enter neurons producing transient intracellular Ca2+ signals. VDCCs are formed as a complex of several different subunits: alfa1, alfa2delta, beta1-4, and gamma. The alfa1 subunit forms the ion conducting pore. The beta subunit contributes to the function of the calcium channel. Specifically, the beta-3 subunit regulates activation and inactivation of the channels through phosphorylation. The beta-3 subunit is most prevalent in the brain but it can also be found in the lungs, heart, aorta, trachea and pancreatic islets.

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