Laquinimod is an orally-available. quinolinone-based, broad spectrum immunomodulator with anti-inflammatory activity, most likely by effecting a T-helper cell 1 to 2 cytokine shift. [1] Additionally it reduces antigen presentation and the effect on migration of T-cells. Laquinimod is also believed to provide a neuroprotective effect and may have application to relapsing-remitting multiple sclerosis (RRMS). [2]In animal models for multiple sclerosis, Laquinimod reversed established relapsing remitting experimental autoimmune encephalomyelitis (RR EAE) and was associated with reduced CNS inflammation, decreased Th1 and Th17 responses, and an increase in regulatory T cells. [3]
Technical information:
Chemical Formula: | C19H17ClN2O3 | |
CAS #: | 248281-84-7 | |
Molecular Weight: | 356.8 | |
Purity: | > 98% | |
Appearance: | White solid | |
Chemical Name: | 5-chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide | |
Solubility: | Up to 22 mM in DMSO | |
Synonyms: | ABR-215062, ABR 215062, ABR215062, Laquinimod |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
1. | "Laquinimod for relapsing-remitting multiple sclerosis" National Horizon Scaning Centre technology summary, Aug. 2011. |
2. | West et al., Profile of oral laquinimod and its potential in the treatment of multiple sclerosis. Degenerative Neurological Muscular Disease 2011, 1, 25-32. |
3. | Schulze-Topphoff et al., Laquinimod, a quinoline-3-carboxamide, induces type II myeloid cells that modulate central nervous system autoimmunity. PLoS ONE 2012, 7(3), e33797. Pubmed ID:22479444 |
Other Information:
Product Specification (pdf) MSDS (pdf) Certificate of Analysis is available upon request.
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grace粉末来配制,按说明书上的话加入碳酸氢钠外就不用加入
别的东西了,请问是否可以直接过滤用了:
在问,我们同一楼的另外一个实验室配制的时候加入了
水解乳蛋白和酵母粉,是否有这个必要,谢谢.在线,急等
不过因为食品添加剂种类很多,适应范畴和添加量都是规定的,如果你未按gb2760的规定使用,可能构成违法,具体是否是犯罪,要看具体的性质。
比如:二氧化钛(就是食品级的钛白粉)允许在允许在膨化食品、果冷、凉果等类限量使用,如果你在肉制品中使用,属于超范围墙使用,就是违法行为。
其次是超量使用,一般超量使用,又没有构成严重后果,属滥用食品添加剂,一般不按犯罪处理。
但超范围使用,加上媒体炒作的话,可能就麻烦了,因为公-安-执-法部门对此不太专业,往往会有意无意的扩大化,有可能会按刑法143条,生产销售伪劣食品罪起诉。
要注意:食品添加剂和非法添加物的区别,食品添加剂是国家允许使用的物质,而非法添加剂则是指食品及添加剂以外的物质,如三聚氰胺、吊白块、苏丹红等,不是食品添加剂,如果使用此类物质,则构成犯罪。
求助日本《医药品添加物事典》关于羟苯丙酯钠在口服溶液剂中最大用量
相容性药品包装材料与药物相容性试验指导原则2.pdf(43.35k)
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