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Tocris/Minocycline hydrochloride/3268/50/50 mg

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Tocris/Minocycline hydrochloride/3268/50/50 mg

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Tocris Bioscience

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3268/50

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Description:Antibiotic.Displaysneuroprotectiveeffects

ChemicalName:[4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Tetracyclineantibiotic.Displaysneuroprotective,antiapoptotic,anti-inflammatoryandantimicrobialeffects.Actsasamatrixmetalloproteinase(MMP)inhibitor;attenuatesdiseaseseverityinmousemodelsofmultiplesclerosis.Orallyactiveandbrainpenetrant.Allowsformationofextendedpluripotentstem(EPS)cellsincombinationwithCHIR99021(Cat.No.4423),(S)-(+)-Dimethindenemaleate(Cat.No.1425)andhumanleukemiainhibitoryfactor.

TechnicalData

M.Wt	493.94
Formula	C₂₃H₂₇N₃O₇.HCl
Storage	Desiccateat+4°C
Purity	≥98%(HPLC)
CASNumber	13614-98-7
PubChemID	54685925
InChIKey	WTJXVDPDEQKTCV-VQAITOIOSA-N
Smiles	NC(C4=C(O)[C@@H](N(C)C)[C@@]3([H])[C@](C4=O)(O)C(O)=C2C(C1=C(O)C=CC(N(C)C)=C1C[C@]([H])2C3)=O)=O.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	49.39	100
	water	12.35	25

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight493.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.02mL	10.12mL	20.25mL
5mM	0.4mL	2.02mL	4.05mL
10mM	0.2mL	1.01mL	2.02mL
50mM	0.04mL	0.2mL	0.4mL

ProductDatasheets

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BiologicalActivity

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