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Tocris/PF 945863/4419/10/10 mg

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Tocris Bioscience

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4419/10

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Description:Macrolideantibiotic

ChemicalName:(3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)tetrone

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Macrolideantibiotic.Activeagainstmultidrugresistantrespiratorytractbacterialstrains.Doesnothavethehepatotoxicsideeffectsassociatedwithtelithromycin.Orallyactive.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

TechnicalData

M.Wt	824.01
Formula	C₄₄H₆₅N₅O₁₀
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	893556-85-9
PubChemID	90488939
InChIKey	FATPJRUUPNLGGR-ACVHMLGSSA-N
Smiles	O=C(N2C3CN([C@H](C)C4=C(C=CC=N5)C5=NC=C4)C3)O[C@](C2[C@H]1C)(C)[C@@H](CC)OC([C@H](C)C([C@H](C)[C@@H](O[C@@]6([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O6)[C@](C)(OC)C[C@@H](C)C1=O)=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	82.4	100
	ethanol	82.4	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight824.01.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.21mL	6.07mL	12.14mL
5mM	0.24mL	1.21mL	2.43mL
10mM	0.12mL	0.61mL	1.21mL
50mM	0.02mL	0.12mL	0.24mL

ProductDatasheets

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BiologicalActivity

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TechnicalData

SolubilityData

PreparingStockSolutions

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