BiologicalActivity
Adenosineanalog;antifungalantibiotic.InhibitsRNAself-cleavageinHEK79cellsandPI3-kinaseactivityinA431epidermoidcarcinomacellmembranefractions.Alsoinhibitsthapsigargin-inducedXBP1-luciferaseactivationandinducesapoptosisinmultiplemyelomacelllines.
TechnicalData
| M.Wt | 291.26 |
| Formula | C12H13N5O4 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 606-58-6 |
| PubChemID | 12444444 |
| InChIKey | XOKJUSAYZUAMGJ-NNXMZFEESA-N |
| Smiles | NC1=C2C(N([C@@H]3O[C@H](CO)[C@H](O)[C@@H]3O)C=C2C#N)=NC=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.13 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight291.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.43mL | 17.17mL | 34.33mL |
| 5mM | 0.69mL | 3.43mL | 6.87mL |
| 10mM | 0.34mL | 1.72mL | 3.43mL |
| 50mM | 0.07mL | 0.34mL | 0.69mL |
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