InVivo TransfectionReagents:
Althoughtransfectionreagentswhichareusuallypositivelychargedvectorsexposehighgenetransferactivityin vitro,systemicadministrationofsuchparticlesisratherrestricted.Aftertailveininjectionofdifferentpositivelychargedlipo-andpolyplexesintomice,complexeswererapidlyclearedfromthecirculationandmainlyaccumulatedinthelungduetotheunspecificbindingwithextracellularcomponents. 
AcartoonshowingshieldedGenJet™PlustransfectionreagentforinvivoDNAtransfectionToeliminatetheunspecificinteractionbetweencationicnonviralvectorwithbloodcomponentsincirculation,weutilizedGenJet™Plusreagentasbackboneandcross-linkedashieldingpeptide(SP)withaminegroupofneutrallipidofthebackbone.TheinitialtestingresultsshowedthatadministrationofshieldedGenJet™Plusdidnotinduceerythrocyteaggregation.InsteadsystematicinjectionofshieldedGenJet™Plusledtoenhancedsystematiccirculationwithsignificantimprovementofrenillaluciferaseexpressioninlung,spleenandlivercomparedwithcontrolGenJet™Pluswithoutshieldpeptide.
| 型号 | 产品名称- | 价格 |
|---|---|---|
| SL100500 | GenJet™PlusDNAInVivoTranfectionReagentDescriptionGenJet™PlusDNAInVivoTranfectionReagentwasformulatedfromitsInVitrotransfectionreagentwithadditionofseveralproprietarypeptides.Withnewchemistry,theDNAcondensinggroupsweresignificantlyincreasedincomparisonoftheoriginalformulation.AshieldpeptidewasalsolinkedtothebackbonetopreventInVivoenvironmentinterferences,leadingtohighInVivotransfectionefficiency.GenJet™Pluswasconfirmedtogivebest... | ¥1,980.00 |
| SL100501 | PepJet™DNAInVivoTranfectionReagentDescriptionPepJet™DNAInVivoTranfectionReagentisanovelcationicpeptidebasedDNAdeliverytool.This28amino-acidslongpeptideisaccidentllyidentifiedasastrongvectorindeliveringDNAinvivo.Withhelpofproteinalignmentandsimulationsoftware,thepeptidewassynthesized,refined,screenedandvalidatedbysimulatingavirusprotein.AshieldpeptidewasalsolinkedtothebackbonetopreventInVivoenvironmentinterferences,leadingto... | ¥2,580.00 |
GenJet™PlusDNAInVivoTranfectionReagent
价格:¥1,980.00
目录号:SL100500
包装:1.0ml
DescriptionGenJet™PlusDNAInVivoTranfectionReagentwasformulatedfromitsInVitrotransfectionreagentwithadditionofseveralproprietarypeptides.Withnewchemistry,theDNAcondensinggroupsweresignificantlyincreasedincomparisonoftheoriginalformulation.AshieldpeptidewasalsolinkedtothebackbonetopreventInVivoenvironmentinterferences,leadingtohighInVivotransfectionefficiency.GenJet™Pluswasconfirmedtogivebestrenillaluciferaseexpressioninlung,spleen,liverandkidney. StorageConditionStoreat4°C.Ifstoredproperly,theproductisstablefor12monthsorlonger.ComparisonofthedeliveryefficienciestodifferentorgansinmiceofaplasmidcontainingtheRenillaluciferasegenemediatedbyGenJet™Plus.
DNA In Vivo Tranfection Reagent价格: ¥2,580.00目录号: SL100501包装: 1.0 ml DescriptionPepJet™DNAInVivoTranfectionReagentisanovelcationicpeptidebasedDNAdeliverytool.This28amino-acidslongpeptideisaccidentllyidentifiedasastrongvectorindeliveringDNAinvivo.Withhelpofproteinalignmentandsimulationsoftware,thepeptidewassynthesized,refined,screenedandvalidatedbysimulatingavirusprotein.AshieldpeptidewasalsolinkedtothebackbonetopreventInVivoenvironmentinterferences,leadingtohighInVivotransfectionefficiency.PepJet™wasconfirmedtogivebestrenillaluciferaseexpressioninlung,liver,spleenandkidney. StorageConditionStoreat4°C.Ifstoredproperly,theproductisstablefor12monthsorlonger.ComparisonofthedeliveryefficienciestodifferentorgansinmiceofaplasmidcontainingtheRenillaluciferasegenemediatedbyPepJet™reagent.
