BiologicalActivity
Antifungalantibioticthatisaninhibitorofthenuclearexportofproteins;actsbybindingdirectlytoandinhibitingCRM1/exportin-1.InhibitsthenuclearexportoftheHIVregulatoryproteinRevandstABIlizesp53.Antitumorinvitroandinvivo.
TechnicalData
| M.Wt | 540.74 |
| Formula | C33H48O6 |
| Storage | Desiccateat-20°C |
| CASNumber | 87081-35-4 |
| PubChemID | 57459335 |
| InChIKey | YACHGFWEQXFSBS-RJXCBBHPSA-N |
| Smiles | CCC(C=C[C@@H]1OC(=O)C=C[C@@H]1C)=C/[C@H](C)CC=CC(C)=C[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)CC(C)=CC(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleinethanol(suppliedpre-dissolvedinanhydrousethanol,27µg/ml) |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight540.74.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.85mL | 9.25mL | 18.49mL |
| 5mM | 0.37mL | 1.85mL | 3.7mL |
| 10mM | 0.18mL | 0.92mL | 1.85mL |
| 50mM | 0.04mL | 0.18mL | 0.37mL |
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