BiologicalActivity
Exhibitsantiproliferativeandpro-apoptoticeffectsincarcinomacellsanddisplayscytotoxicactivityagainstapanelof60cancercelllines(meanIC50=47nM).Activitydecreasesrateofcelldivisionandincreasesmitosisdurationinvitro.AlsomodulatestheRho/ROCK/LIMkinase/cofilinpathway;stimulatesRhoAactivationandinducesactinpolymerization.
TechnicalData
| M.Wt | 307.26 |
| Formula | C14H13NO7 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 29477-83-6 |
| PubChemID | 72376 |
| InChIKey | LZAZURSABQIKGB-AEKGRLRDSA-N |
| Smiles | OC1=C(C(N[C@]4([H])C3=C[C@H](O)[C@@H](O)[C@H]4O)=O)C3=CC2=C1OCO2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.73 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight307.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.25mL | 16.27mL | 32.55mL |
| 5mM | 0.65mL | 3.25mL | 6.51mL |
| 10mM | 0.33mL | 1.63mL | 3.25mL |
| 50mM | 0.07mL | 0.33mL | 0.65mL |
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