商品信息
联系客服
郑重提醒:
无质量问题不接受退换货,下单前请仔细核对信息。
下单后请及时联系客服核对商品价格,订单生效后再付款。
Tocris/Pyridostatin pentahydrochloride/4763/50/50 mg
免费咨询热线
4000-520-616
Description:StABIlizesG-quadruplexes;inducesDNAdamageandcellcyclearrest
ChemicalName:4-(2-Aminoethoxy)N2,N6-bis[(4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinecarboxamidepentahydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
BindsandstabilizesG-quadruplexes,inducingDNAdamageandcellcyclearrest(Kd=490nM);targetstheproto-oncogeneSrc,reducingSrcproteinabundanceandSrc-dependentmotilityinhumanbreastcancercells.AlsotargetstelomericG-quadruplexes,inducingtelomerasedysfunction.ActivatestheDNA-dependentproteinkinasecatalyticsunbunit(DNA-PKcs).
TechnicalData
M.Wt | 778.94 |
Formula | C31H32N8O5.5HCl |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
PubChemID | 78243739 |
InChIKey | SRIZPFGTXSQRFM-UHFFFAOYSA-N |
Smiles | NCCOC1=CC(C(NC2=NC(C=CC=C3)=C3C(OCCN)=C2)=O)=NC(C(NC4=CC(OCCN)=C(C=CC=C5)C5=N4)=O)=C1.Cl.Cl.Cl.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
water | 77.89 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight778.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.28mL | 6.42mL | 12.84mL |
5mM | 0.26mL | 1.28mL | 2.57mL |
10mM | 0.13mL | 0.64mL | 1.28mL |
50mM | 0.03mL | 0.13mL | 0.26mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
▍
品牌分类
▍
官网分类
▍
品牌问答
暂无品牌问答