3-hydroxy Anthranilic Acidco-antioxidant |
Sample solution is provided at 25 µL, 10mM.
Quality Control & MSDS
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- Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
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Cas No. | 548-93-6 | SDF | Download SDF |
Synonyms | 3-HAA,NSC 522891 | ||
Chemical Name | 2-amino-3-hydroxy-benzoic acid | ||
Canonical SMILES | OC(C1=C(N)C(O)=CC=C1)=O | ||
Formula | C7H7NO3 | M.Wt | 153.1 |
Solubility | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide | Storage | Store at -20°C |
Physical Appearance | A crystalline solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. |
3-Hydroxyanthranilic acid (3-HAA) is an intermediate in the metabolism of the amino acid tryptophan. 3-HAA is an aminobenzoic acid generated by substitution of benzoic acid at C-2 with an amine group and at C-3 by a hydroxy group. 3-Hydroxyanthranilic acid is a new antioxidant isolated from methanol extract of tempeh [1].
Tryptophan metabolism by the kynurenine pathway (KP) plays an important role in the pathogenesis of inflammatory, infectious, and degenerative diseases [2]. 3-HAA effectively suppressed glial cytokine and chemokine expression and reduced cytokine-induced neuronal death [2]. In astrocytes, 3-HAA induced the expression of hemeoxygenase-1 (HO-1), an antioxidant enzyme with anti-inflammatory and cytoprotective properties. In cultured adult human astrocytes, 3-HAA induced HO-1 expression, which has also been observed after injection to mouse brains [2]. 3-HAA acted as a co-antioxidant for α-tocopherol, inhibiting human low density lipoprotein and plasma lipid peroxidation [3]. 3-HAA inhibited nitric oxide (NO) synthase in macrophages and stimulated TGF-β production, suppressing pro-inflammatory activity of Th1 cells [1].
References:[1] Stone T W, Stoy N, Darlington L G. An expanding range of targets for kynurenine metabolites of tryptophan[J]. Trends in pharmacological sciences, 2013, 34(2): 136-143.[2] Krause D, Suh H S, Tarassishin L, et al. The tryptophan metabolite 3-hydroxyanthranilic acid plays anti-inflammatory and neuroprotective roles during inflammation: role of hemeoxygenase-1[J]. The American journal of pathology, 2011, 179(3): 1360-1372.[3] Thomas, S.R.,Wittig, P.K. and Stocker, R. 3-Hydroxyanthranilic acid is an efficient, cell-derived co-antioxidant for α-tocopherol, inhibiting human low density lipoprotein and plasma lipid peroxidation. The Journal of Biological Chemisty 271, 2714-32721 (1996).
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各位大侠:
颗粒筛分及检测堆实密度的意义何在?检测堆实密度时的振荡次数一般是多少?是统一规定的还是各国有各自的要求?
请不吝赐教!!!小弟在此先抱拳谢过。。。
使用方法: 经纬密度仪是用于对梭织布进行密度检验的仪器。
它类似一个放大镜,旁边有个旋钮,可以让指示针移动,便于计数。
经密的检验:把布纵向放置于检验者的面前,检验仪置于布的任意位置。
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