Tocris中国采购 Tocris抗体,Tocris/GW 788388/3264/50/50 mg,氨基酸,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/GW 788388/3264/50/50 mg

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Tocris Bioscience

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3264/50

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4000-520-616

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Description:PotentandselectiveinhibitorofTGF-βRI

ChemicalName:4-[4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)-benzamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentinhibitoroftransforminggrowthfactor-βtypeIreceptor(ALK5)(IC₅₀valuesare18and93nMforALK5bindingandforTGF-βcellularassayrespectively).Inhibitsesophagealsquamouscellcarcinoma(ESCC)-inducedneoangiogenesis.Orallyactive.

LicensingInformation

SoldforresearchpurposesunderagreementfromGlaxoSmithKline

CompoundLibraries

GW788388isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	425.48
Formula	C₂₅H₂₃N₅O₂
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	452342-67-5
PubChemID	10202642
InChIKey	SAGZIBJAQGBRQA-UHFFFAOYSA-N
Smiles	O=C(NC5CCOCC5)C(C=C4)=CC=C4C1=CC(C2=CNN=C2C3=CC=CC=N3)=CC=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	42.55	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight425.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.35mL	11.75mL	23.5mL
5mM	0.47mL	2.35mL	4.7mL
10mM	0.24mL	1.18mL	2.35mL
50mM	0.05mL	0.24mL	0.47mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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