Overview:
Potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available.
References:
1. L Kruidenier et al. Nature 2012 488:404
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如图,方法是默克给的厂家标准,样品为叔丁醇
现在想把KOH滴定液换成NaOH滴定液,但是领导死活让找依据不然就要做验证
我想知道有没有哪位大神知道这个方法的具体出处。
最好权威一点
暂无品牌问答