请使用支持JavaScript的浏览器! Adipogen/antiCathepsin D, mAb (AF5H4)/YIFLFMA0322/100 µl_蚂蚁淘,【正品极速】生物医学科研用品轻松购|ebiomall -蚂蚁淘商城
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Adipogen/antiCathepsin D, mAb (AF5H4)/YIFLFMA0322/100 µl
来自 : mayitao
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ProductDetails
SynonymsCPSD;CTSD;EC=3.4.23.5
ProductTypeMonoclonalAntibody
Properties
CloneAF5H4
IsotypeMouseIgG1κ
Immunogen/AntigenRecombinanthumanHis-CathepsinDproteinpurifiedfromE.coli.
ApplicationELISA
WesternBlot(1:2,000)
CrossreactivityHuman
PurityDetailAmmoniumsulfateprecipitation.
FormulationLiquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol.
OtherProductDataClickhereforOriginalManufacturerProductDatasheet
Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.
DeclarationManufacturedbyAbFrontier
ShippingandHandling
ShippingBLUEICE
ShortTermStorage+4°C
LongTermStorage-20°C
Use/StabilityStableforatleast1yearafterreceiptwhenstoredat-20°C.
Documents
MSDSNo
ProductSpecificationSheet
DatasheetDownloadPDF
CathepsinD(CatD)isaubiquitouslyexpressedlysosomalaspartylproteaseinvolvedinthenormaldegradationofproteinsapoptosisandautophagy.HumanCatDissynthesizedontheendoplasmicreticulumasapre-pro-enzyme.PreprocathepsinD(412aa)iscleavedandglycosylatedtoformaninactiveprocathepsinD(392aa)andthenfurthercleavedtogenerateanactiveintermediate(348aa)single-chainmolecule.TheactiveintermediateisfurtherprocessedintomaturetwochainformofcathepsinD,thisprocessingstepiscarriedoutbycathepsinBorL.Thetwo-chainformconsistsofanaminoterminallightchainandacarboxyl-terminalheavychain.Additionally,severalmoreaminoacidsareremovedfromthecarboxylterminusoftheheavychain.ProcathepsinD(pCD),secretedfromcancercells,actsasamitogenonbothcancerandstromalcellsandstimulatestheirproinvasiveandpro-metastaticproperties.Acidproteaseactiveinintracellularproteinbreakdown.InvolvedinthepathogenesisofseveraldiseasessuchasbreastcancerandpossiblyAlzheimerdisease
ProductReferences
1)ZaidiNetal.,(2008)BiochemBiophysResCommun7;376(1):5-9.(General)
2)Liaudet-CoopmanEetal.,(2006)CancerLett237;167-179.(General)
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