TheJ11dmonoclonalantibodyreactswithmouseCD24alsoknownasheatstableantigen(HSA),a35-50kDaglycosylatedmembraneprotein.CD24isexpressedbyerythrocytes,granulocytes,monocytes,andlymphocytes.ImmatureBcellsinbonemarrowandspleenofadultmiceexpresshighlevelsofCD24,whilematureperipheralBcellsexpressintermediatelevelsofCD24.TheexpressionofCD24hasbeenusedtoresolvestagesofBcelllymphopoiesisinmousebonemarrow.IthasbeenreportedthatP-selectin(CD62P)bindstoCD24.TheJ11dantibodyhasbeenshowntodepleteCD24+cellswhenadministeredinvivo.
Isotype | RatIgM, κ |
RecomendedIsotypeControl(s) | InVivoMAbpolyclonalratIgG |
RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
Immunogen | C3H/HeJmousethymocytes |
ReportedApplications | invitroCD24+celldepletion |
Endotoxin |
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Purity |
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Formulation |
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Sterility | 0.2μMfiltered |
Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
Purification | T-Gel |
Storage | Undilutedat4°Cinthedark |