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ReliaTech/Rabbit AntiMouse PlGF/103PA04S/100 µg
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Antibodygeneration:

Placentagrowthfactor(PlGF)isamemberofthevascularendothelialgrowthfactor(VEGF)familyofgrowthfactors.PlGFandVEGFshareprimarystructuralaswellaslimitedaminoacidsequencehomologywiththeAandBchainsofPDGF.Alleightcysteineresiduesinvolvedinintraandinterchaindisulfidesareconservedamongthesegrowthfactors.Asaresultofalternativesplicing,threePlGFRNAsencodingmonomerichumanPlGF1,PlGF2andPlGF3isoformprecursorscontaining149,179and219aminoacidresidues,respectively,havebeendescribed.Innormalmousetissues,onlyonemousePlGFmRNAencodingtheequivalentofhumanPlGF2hasbeenidentified.MousePlGFshares65%aminoacididentitywithhumanPlGF2.ThegeneforPlGFhasbeenmappedtomousechromosome12andhumanchromosome14.PlGFbindswithhighaffinitytoFlt1,butnottoFlk1/KDR.

Antigen:

RecombinantmousePlGF(RT#M30-020)

Stability:

Thelyophilizedantibodyisstableatroomtemperatureforupto1month.Thereconstitutedantibodyisstableforatleasttwoweeksat2-8°C.Frozenaliquotsarestableforatleast6monthswhenstoredat-20°C.

Reconstitution:

Centrifugevialpriortoopening.Reconstituteinsterilewatertoaconcentrationof0.1-1.0mg/ml.

Description:

Placentagrowthfactor(PlGF)isamemberofthevascularendothelialgrowthfactor(VEGF)familyofgrowthfactors.PlGFandVEGFshareprimarystructuralaswellaslimitedaminoacidsequencehomologywiththeAandBchainsofPDGF.Alleightcysteineresiduesinvolvedinintraandinterchaindisulfidesareconservedamongthesegrowthfactors.Asaresultofalternativesplicing,threePlGFRNAsencodingmonomerichumanPlGF1,PlGF2andPlGF3isoformprecursorscontaining149,179and219aminoacidresidues,respectively,havebeendescribed.Innormalmousetissues,onlyonemousePlGFmRNAencodingtheequivalentofhumanPlGF2hasbeenidentified.MousePlGFshares65%aminoacididentitywithhumanPlGF2.ThegeneforPlGFhasbeenmappedtomousechromosome12andhumanchromosome14.PlGFbindswithhighaffinitytoFlt1,butnottoFlk1/KDR.
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