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Tocris/OTX 015/6181/10/10 mg
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Description:BETbromodomaininhibitor;orallybioavailable
ChemicalName:(6S)-4-(4-Chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
BETbromodomaininhibitor(IC50valuesareintherange92-112nM).Inhibitsproliferationandinducesapoptosisofleukemiacelllinesinvitro.DecreasesBRD2,BRD4andc-MYCproteinexpression.Orallybioavailable.
TechnicalData
| M.Wt | 491.99 |
| Formula | C25H22ClN5O2S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 202590-98-5 |
| PubChemID | 9936746 |
| InChIKey | GNMUEVRJHCWKTO-FQEVSTJZSA-N |
| Smiles | CC1=C(C2=C(N3C(C)=NN=C3[C@@H](N=C2C4=CC=C(C=C4)Cl)CC(NC5=CC=C(C=C5)O)=O)S1)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.2 | 100 | |
| ethanol | 9.84 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight491.99.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.03mL | 10.16mL | 20.33mL |
| 5mM | 0.41mL | 2.03mL | 4.07mL |
| 10mM | 0.2mL | 1.02mL | 2.03mL |
| 50mM | 0.04mL | 0.2mL | 0.41mL |
MolarityCalculator
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ReconstitutionCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.
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