Description
AGDVisaC-terminalpeptidesequencefoundonfibrinogenthatisknownasabindingsiteforglycoproteinIIb/IIIa(integrinαIIbβ3);thisbindingisrequiredforplateletadhesionandaggregation.
References
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PodolnikovaNP,GorkunOV,LorethRM,etal.Aclusterofbasicaminoacidresiduesinthegamma370-381sequenceoffibrinogencomprisesabindingsiteforplateletintegrinalpha(IIb)beta3(glycoproteinIIb/IIIa).Biochemistry.2005Dec27;44(51):16920-30.PMID:16363805.
LiuQ,RooneyMM,Kasirer-FriedeA,etal.RoleofthegammachainAla-Gly-Asp-ValandAalphachainArg-Gly-Asp-Sersitesoffibrinogenincoaggregationofplateletsandfibrinogen-coatedbeads.BiochimBiophysActa.1998Jun11;1385(1):33-42.PMID:9630497.