Description
Matrix GLa protein inhibits vascular calcification in a vitamin K-dependent manner. Serum levels of this peptide may be used as a biomarker for renal failure, diabetes, and cardiovascular events.
References
McCarty MF, DiNicolantonio JJ. The molecular biology and pathophysiology of vascular calcification. Postgrad Med. 2014 Mar;126(2):54-64. PMID: 24685968.
Schurgers LJ, Uitto J, Reutelingsperger CP. Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization. Trends Mol Med. 2013 Apr;19(4):217-26. PMID: 23375872.