BiologicalActivity
PotentinhibitorofAβoligomerandfibrilformation(IC50=50nMforformationoffibrilsfromAβ1-42).ReducescytotoxicityofAβoligomersandincreasescellviABIlityinneuronalcells.SignificantlyextendsLifespanofDrosophilaexpressinghumanAβ1-42.
TechnicalData
| M.Wt | 360.36 |
| Formula | C21H16N2O4 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 185351-19-3 |
| PubChemID | 56605052 |
| InChIKey | DZZUYZXINNHEGM-SFHVURJKSA-N |
| Smiles | O=C1C4=C(C=CC=C4)C(C(N[C@H]([C@@](O)=O)CC3=CNC2=CC=CC=C23)=C1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.04 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight360.36.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.78mL | 13.88mL | 27.75mL |
| 5mM | 0.56mL | 2.78mL | 5.55mL |
| 10mM | 0.28mL | 1.39mL | 2.78mL |
| 50mM | 0.06mL | 0.28mL | 0.56mL |
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